Rapchuk I L, O'Connell L, Liessmann C D, Cornelissen H R, Fraser J F
Departments of Anaesthesia and Critical Care Research Group, The Prince Charles Hospital, Chermside, Queensland, Australia.
Anaesth Intensive Care. 2010 May;38(3):445-51. doi: 10.1177/0310057X1003800306.
This study evaluated whether perioperative administration of gabapentin in cardiac surgery patients could reduce postoperative opioid consumption, postoperative sleep or perceived quality of recovery. This randomised controlled trial assigned 60 patients undergoing cardiac surgery to receive 1200 mg of gabapentin or placebo two hours preoperatively, and then 600 mg of gabapentin or placebo twice a day for the next two postoperative days. Postoperative opioid use was measured by the amount of fentanyl used in the first 48 hours postoperatively. Pain at rest and with movement at 12, 24, 48 and 72 hours after surgery, sleep scores on postoperative days two and three and patient-perceived quality of recovery were also assessed. Fentanyl use, visual analog pain scores, sleep scores, adjunctive pain medication use and number of anti-emetics given were not significantly different between the gabapentin and placebo groups. The incidence of side-effects was similar between the gabapentin and placebo groups, and no difference was found between groups in relation to quality of recovery. These findings indicate that preoperative use of gabapentin followed by postoperative dosing for two days did not significantly affect the postoperative pain, sleep, opioid consumption or patient-perceived quality of recovery for patients undergoing cardiac surgery.
本研究评估了心脏手术患者围手术期给予加巴喷丁是否能减少术后阿片类药物的用量、改善术后睡眠或患者感知的恢复质量。这项随机对照试验将60例接受心脏手术的患者分为两组，一组在术前两小时接受1200毫克加巴喷丁，另一组接受安慰剂，然后在术后两天内，两组患者每天两次分别接受600毫克加巴喷丁或安慰剂。术后阿片类药物的使用量通过术后头48小时内芬太尼的用量来衡量。同时还评估了术后12、24、48和72小时的静息痛和活动痛、术后第二天和第三天的睡眠评分以及患者感知的恢复质量。加巴喷丁组和安慰剂组在芬太尼用量、视觉模拟疼痛评分、睡眠评分、辅助性镇痛药物的使用以及止吐药的使用次数方面均无显著差异。加巴喷丁组和安慰剂组的副作用发生率相似，两组在恢复质量方面也未发现差异。这些研究结果表明，术前使用加巴喷丁并在术后连续给药两天，对接受心脏手术患者的术后疼痛、睡眠、阿片类药物用量或患者感知的恢复质量并无显著影响。
