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口服加巴喷丁对术后寒战的预防效果：一项随机对照试验的荟萃分析。

Prophylactic efficacy of oral gabapentin on postoperative shivering: A meta-analysis of randomized controlled trials.

作者信息

Liang Xiao, Chen Ming, Hong Aonan, Gu Zhen, Jiang Jing, Chen Yanchun, Zhu Minmin, Tian Weiqian

机构信息

Department of Anesthesiology, Jiangnan University Medical Center (Wuxi No.2 People's Hospital), Affiliated Wuxi Clinical College of Nantong University, Wuxi, China.

Department of Anesthesiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.

出版信息

Medicine (Baltimore). 2025 Mar 7;104(10):e41421. doi: 10.1097/MD.0000000000041421.

DOI:10.1097/MD.0000000000041421
PMID:40068032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11902932/
Abstract

BACKGROUND

Postoperative shivering may lead to severe side effects during postoperative care, particularly in patients with impaired cardiopulmonary function. The efficacy of oral gabapentin as a preventive strategy for postoperative shivering has not been quantitatively analyzed. In this meta-analysis, we aimed to evaluate the effectiveness of gabapentin as a drug for treating postoperative shivering.

METHODS

A review of the Cochrane Library, PubMed, and Embase was conducted by 2 researchers for randomized controlled trials (RCTs). In this meta-analysis, Review Manager was used to analyze these RCTs on oral gabapentin for postoperative shivering.

RESULTS

Six trials with 544 patients were included in our meta-analysis. Prophylactic oral gabapentin reduced postoperative shivering compared with placebo (pooled risk ratio [RR]: 0.38, 95% confidence interval [CI]: 0.25-0.57). The anti-shivering effect could be achieved after both general anesthesia (pooled RR of 3 trails: 0.28, 95% CI: 0.14-0.56) and orthopedic surgery (pooled RR of 4 trails: 0.38, 95% CI: 0.24-0.58). Meanwhile, gabapentin also could decrease postoperative vomiting (POV; pooled RR 0.35, 95% CI 0.16-0.77).

CONCLUSION

Our current meta-analysis shows that compared with placebo, oral gabapentin can reduce the incidence of postoperative shivering. This result also provides new evidence to strengthen the clinical application value of gabapentin in the conventional treatment of POV.

PROSPERO REGISTRATION NUMBER

CRD42022340734.

摘要

背景

术后寒战可能会在术后护理期间导致严重的副作用，尤其是在心肺功能受损的患者中。口服加巴喷丁作为术后寒战预防策略的疗效尚未进行定量分析。在这项荟萃分析中，我们旨在评估加巴喷丁作为治疗术后寒战药物的有效性。

方法

由2名研究人员对Cochrane图书馆、PubMed和Embase进行检索，以查找随机对照试验（RCT）。在这项荟萃分析中，使用Review Manager对这些关于口服加巴喷丁治疗术后寒战的RCT进行分析。

结果

我们的荟萃分析纳入了6项试验，共544例患者。与安慰剂相比，预防性口服加巴喷丁可降低术后寒战的发生率（合并风险比[RR]：0.38，95%置信区间[CI]：0.25 - 0.57）。全身麻醉（3项试验的合并RR：0.28，95% CI：0.14 - 0.56）和骨科手术后（4项试验的合并RR：0.38，95% CI：0.24 - 0.58）均可实现抗寒战效果。同时，加巴喷丁还可减少术后呕吐（POV；合并RR 0.35，95% CI 0.16 - 0.77）。

结论

我们目前的荟萃分析表明，与安慰剂相比，口服加巴喷丁可降低术后寒战的发生率。这一结果也为加强加巴喷丁在POV常规治疗中的临床应用价值提供了新证据。

PROSPERO注册号：CRD42022340734。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9458/11902932/da05b357f59a/medi-104-e41421-g008.jpg
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