Invasive Bacterial Infections Unit, Neisseria Unit, and National Reference Center for Meningococci, Institut Pasteur, Paris, France.
J Infect Dis. 2010 Jul 15;202(2):247-50. doi: 10.1086/653583.
In France, there have been variations in the incidence of invasive meningococcal infection due to serogroup C isolates. Infection peaks were observed in 1992 and 2003 that involved isolates of phenotypes C:2a:P1.5,2 and/or C:2a:P1.5, which belong to the sequence type 11 (ST-11) clonal complex. We report an emergence of isolates belonging to the ST-11 clonal complex since 2003. These isolates displayed a new phenotype, C:2a:P1.7,1, caused infections that occurred as clusters, and were associated with increased infection severity and high virulence in mice. These isolates may be responsible for a peak in the incidence of serogroup C meningococcal infection in France, for which there is no routine vaccination to date.
在法国，由于 C 群分离株的存在，侵袭性脑膜炎球菌感染的发病率有所不同。1992 年和 2003 年观察到感染高峰，涉及表型 C:2a:P1.5,2 和/或 C:2a:P1.5,1 的分离株，这些分离株属于序列型 11（ST-11）克隆复合体。自 2003 年以来，我们报告了属于 ST-11 克隆复合体的分离株的出现。这些分离株表现出一种新的表型 C:2a:P1.7,1，引起了群集性感染，与感染严重程度增加和小鼠高毒力有关。这些分离株可能是导致法国 C 群脑膜炎球菌感染发病率高峰的原因，目前尚无针对该菌的常规疫苗。
