Umei H, Yamagishi S-I, Imaizumi T
Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan.
J Int Med Res. 2010 Mar-Apr;38(2):443-8. doi: 10.1177/147323001003800207.
Pigment epithelium-derived factor (PEDF), a glycoprotein with neuronal differentiating activity, possesses anti-inflammatory properties both in cell culture and animal models. However, the relationship between serum levels of PEDF and high-sensitivity C-reactive protein (hs-CRP), one of the representative biomarkers for inflammation in humans, is largely unknown. This study investigated whether serum PEDF levels were associated with hs-CRP in 120 apparently healthy unmedicated Japanese subjects (93 males, 27 females; mean age 58.0 years). All subjects underwent a complete history and physical examination, including blood chemistries, anthropometric and metabolic variables. Multiple regression analysis found that serum hs-CRP, creatinine and triglyceride levels, and the homeostasis model assessment of insulin resistance (HOMA-IR) and body mass index were significantly and independently associated with serum PEDF levels. It is concluded that, serum levels of PEDF are associated with serum levels of hs-CRP independently of anthropometric, metabolic and renal function variables. The results also suggest that serum PEDF levels may be elevated as a counter-system against subclinical inflammation.
色素上皮衍生因子（PEDF）是一种具有神经元分化活性的糖蛋白，在细胞培养和动物模型中均具有抗炎特性。然而，血清中PEDF水平与人类炎症的代表性生物标志物之一高敏C反应蛋白（hs-CRP）之间的关系在很大程度上尚不清楚。本研究调查了120名表面健康且未用药的日本受试者（93名男性，27名女性；平均年龄58.0岁）血清PEDF水平是否与hs-CRP相关。所有受试者均接受了全面的病史和体格检查，包括血液化学、人体测量和代谢变量。多元回归分析发现，血清hs-CRP、肌酐和甘油三酯水平，以及胰岛素抵抗的稳态模型评估（HOMA-IR）和体重指数与血清PEDF水平显著且独立相关。研究得出结论，血清PEDF水平与hs-CRP血清水平相关，且独立于人体测量、代谢和肾功能变量。结果还表明，血清PEDF水平可能作为对抗亚临床炎症的一种反系统而升高。
