Zhou P, Sha H, Zhu J
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
J Int Med Res. 2010 Mar-Apr;38(2):611-9. doi: 10.1177/147323001003800223.
As a new member of the CD4(+) effector T-cell family, T-helper 17 (Th17) cells, have emerged as an important mediator in inflammatory and autoimmune diseases. Th17 cells preferentially produce interleukin (IL)-17A, IL-17F, IL-21, IL-22, and IL-26 in humans. Recent studies suggest a potential role for Th17 cells in tumour development. The current study was designed to investigate the possible involvement of Th17 cells in the brain tumour medulloblastoma. Compared with 17 healthy volunteers, 23 patients with medulloblastoma had a higher proportion of Th17 cells in their peripheral blood. Increased populations of Th17 cells were also present in medulloblastoma-infiltrating T-cells. Furthermore, the mRNA levels for Th17-related factors (IL-17, IL-23 and retinoid orphan nuclear receptor) in tumour tissues and the serum concentrations of IL-17 and IL-23 protein were significantly increased in patients with medulloblastoma. The results indicate that Th17 cells may contribute to medulloblastoma pathogenesis.
作为CD4(+)效应T细胞家族的新成员，辅助性T细胞17（Th17）已成为炎症和自身免疫性疾病的重要介质。在人类中，Th17细胞优先产生白细胞介素（IL）-17A、IL-17F、IL-21、IL-22和IL-26。最近的研究表明Th17细胞在肿瘤发展中可能发挥作用。本研究旨在调查Th17细胞在脑肿瘤髓母细胞瘤中的可能作用。与17名健康志愿者相比，23例髓母细胞瘤患者外周血中Th17细胞的比例更高。髓母细胞瘤浸润性T细胞中Th17细胞的数量也有所增加。此外，髓母细胞瘤患者肿瘤组织中Th17相关因子（IL-17、IL-23和视黄酸孤儿核受体）的mRNA水平以及IL-17和IL-23蛋白的血清浓度显著升高。结果表明，Th17细胞可能参与髓母细胞瘤的发病机制。
