Zhang Bin, Rong Guanghua, Wei Huafeng, Zhang Meng, Bi Jianwei, Ma Liye, Xue Xuchao, Wei Guo, Liu Xiaokang, Fang Guoen
Department of General Surgery, Changhai Hospital, The Second Military Medical University, No. 168, Changhai Road, Shanghai 200433, PR China.
Biochem Biophys Res Commun. 2008 Sep 26;374(3):533-7. doi: 10.1016/j.bbrc.2008.07.060. Epub 2008 Jul 23.
Th17 cells have emerged as an important mediator in inflammatory and autoimmune diseases. However, recent studies suggest a potential impact of Th17 cells on tumor. The current study was designed to investigate the possible involvement of Th17 cells in gastric cancer. Compared with healthy volunteers, patients with gastric cancer had a higher proportion of Th17 cells in peripheral blood. Notably, the increased prevalence of Th17 cells was associated with clinical stage. In addition, increased populations of Th17 cells were present in tumor-draining lymph nodes with advanced disease. Furthermore, the mRNA expression levels of Th17-related factors (IL-17, IL-23p19, and RORC) in tumor tissues and the serum concentrations of IL-17 and IL-23 cytokines were significantly increased in patients with advanced gastric cancer. The results indicate that Th17 cells may contribute to gastric cancer pathogenesis.
Th17细胞已成为炎症和自身免疫性疾病中的一种重要介质。然而，最近的研究表明Th17细胞对肿瘤具有潜在影响。本研究旨在调查Th17细胞在胃癌中可能发挥的作用。与健康志愿者相比，胃癌患者外周血中Th17细胞的比例更高。值得注意的是，Th17细胞比例的增加与临床分期相关。此外，在患有晚期疾病的肿瘤引流淋巴结中，Th17细胞数量增加。此外，晚期胃癌患者肿瘤组织中Th17相关因子（IL-17、IL-23p19和RORC）的mRNA表达水平以及IL-17和IL-23细胞因子的血清浓度均显著升高。结果表明，Th17细胞可能参与胃癌的发病机制。
