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I期非小细胞肺癌的立体定向体部放射治疗(立体定向消融放疗)——放射生物学、技术及临床结果的更新

Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage I non-small cell lung cancer--updates of radiobiology, techniques, and clinical outcomes.

作者信息

Hadziahmetovic Mersiha, Loo Billy W, Timmerman Robert D, Mayr Nina A, Wang Jian Z, Huang Zhibin, Grecula John C, Lo Simon S

机构信息

Department of Radiation Oncology, Arthur G. James Cancer Hospital, Ohio State University, Columbus, OH 43210, USA.

出版信息

Discov Med. 2010 May;9(48):411-7.

Abstract

Stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), has emerged as one of the standard treatment options for stage I non-small cell lung cancer (NSCLC), mainly in medically inoperable patients. Its use has also been explored in operable patients. A large body of experience, either from retrospective studies or clinical trials, has been accumulated over the years and more is known about the radiobiology, cancer biology, technical aspects, clinical outcomes, and toxicities of SBRT. This article provides updates of these aspects of SBRT for stage I NSCLC.

摘要

立体定向体部放射治疗(SBRT),也称为立体定向消融放疗(SABR),已成为I期非小细胞肺癌(NSCLC)的标准治疗选择之一,主要用于医学上无法手术的患者。其在可手术患者中的应用也已得到探索。多年来,通过回顾性研究或临床试验积累了大量经验,对SBRT的放射生物学、癌症生物学、技术方面、临床结果和毒性也有了更多了解。本文提供了I期NSCLC的SBRT这些方面的最新信息。

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