LBFA/INSERM 884, Joseph Fourier University, BP53, Grenoble cedex 9, France.
Arch Biochem Biophys. 2010 Sep 1;501(1):158-61. doi: 10.1016/j.abb.2010.05.032. Epub 2010 May 31.
Polyphenols from cinnamon (CN) have been described recently as insulin sensitizers and antioxidants but their effects on the glucose/insulin system in vivo have not been totally investigated. The aim of this study was to determine the effects of CN on insulin resistance and body composition, using an animal model of the metabolic syndrome, the high fat/high fructose (HF/HF) fed rat. Four groups of 22 male Wistar rats were fed for 12 weeks with: (i) (HF/HF) diet to induce insulin resistance, (ii) HF/HF diet containing 20 g cinnamon/kg of diet (HF/HF + CN), (iii) Control diet (C) and (iv) Control diet containing 20 g cinnamon/kg of diet (C + CN). Data from hyperinsulinemic euglycemic clamps showed a significant decrease of the glucose infusion rates in rats fed the HF/HF diet. Addition of cinnamon to the HF/HF diet increased the glucose infusion rates to those of the control rats. The HF/HF diet induced a reduction in pancreas weight which was prevented in HF/HF+CN group (p<0.01). Mesenteric white fat accumulation was observed in HF/HF rats vs. control rats (p<0.01). This deleterious effect was alleviated when cinnamon was added to the diet. In summary, these results suggest that in animals fed a high fat/high fructose diet to induce insulin resistance, CN alters body composition in association with improved insulin sensitivity.
肉桂中的多酚最近被描述为胰岛素增敏剂和抗氧化剂，但它们对体内葡萄糖/胰岛素系统的影响尚未完全研究。本研究旨在使用代谢综合征的动物模型，即高脂肪/高果糖（HF/HF）喂养大鼠，确定 CN 对胰岛素抵抗和身体成分的影响。四组 22 只雄性 Wistar 大鼠分别用以下饮食喂养 12 周：（i）HF/HF 饮食诱导胰岛素抵抗，（ii）HF/HF 饮食中含有 20 g 肉桂/kg 饮食（HF/HF+CN），（iii）对照饮食（C）和（iv）对照饮食中含有 20 g 肉桂/ kg 饮食（C+CN）。高胰岛素正葡萄糖钳夹实验的数据显示，HF/HF 饮食喂养的大鼠葡萄糖输注率显著降低。在 HF/HF 饮食中添加肉桂可使葡萄糖输注率提高至对照大鼠的水平。HF/HF 饮食引起胰腺重量减轻，而 HF/HF+CN 组则可预防这一现象（p<0.01）。与对照大鼠相比，HF/HF 大鼠肠系膜白色脂肪堆积（p<0.01）。当在饮食中添加肉桂时，这种有害影响得到缓解。总之，这些结果表明，在喂食高脂肪/高果糖饮食以诱导胰岛素抵抗的动物中，CN 可改变身体成分，同时提高胰岛素敏感性。
