Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
Nutrients. 2023 Jun 30;15(13):2983. doi: 10.3390/nu15132983.
(1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose-response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose-response meta-analysis was performed to explore the effect of the cinnamon intervention on glycolipid metabolism. We conducted a comprehensive database search for literature published before November 2022. Nonlinear models were used for dose-response relationship analysis. (3) Results: We identified that a cinnamon intervention was effective in controlling triglyceride (TG) levels (mean difference = -7.31; 95%CI: -12.37, -2.25, = 0.005) and low-density lipoprotein cholesterol (LDL-C) levels (mean difference = -6.78; 95%CI: -11.35, -2.22, = 0.004) in type 2 diabetic patients; however, it also was able to increase high-density lipoprotein cholesterol (HDL-C) levels in patients with type 2 diabetes (mean difference = 1.53; 95%CI: 1.01, 2.05, < 0.001). However, the cinnamon intervention had no significant effect on the level of fasting blood glucose, glycated hemoglobin (HbA1c), or total cholesterol (TC) levels. We found a significant effect of the cinnamon intervention dose on the TG level (-nonlinearity = 0.016) and LDL-C (-nonlinearity = 0.019) in the nonlinear dose-response analysis. In the subgroup analysis, we found a hypoglycemic effect with the cinnamon dose ≤1200 mg (mean difference = -11.1, 95%CI: -14.64, -7.58, < 0.001). (4) Conclusion: Cinnamon intervention may be beneficial in lowering TG and LDL-C levels while enhancing HDL-C levels, and the dosage of the intervention was an important factor in influencing the TG and LDL-C levels.
（1）背景：肉桂对 2 型糖尿病患者糖脂水平的调节作用仍存在争议，且关于肉桂与 2 型糖尿病患者糖脂指标的剂量-效应关系研究较少。（2）方法：本剂量-反应荟萃分析旨在探讨肉桂干预对糖脂代谢的影响。我们对截至 2022 年 11 月发表的文献进行了全面的数据库检索。采用非线性模型进行剂量-反应关系分析。（3）结果：我们发现，肉桂干预可有效控制 2 型糖尿病患者的甘油三酯（TG）水平（均差=-7.31；95%CI：-12.37，-2.25， = 0.005）和低密度脂蛋白胆固醇（LDL-C）水平（均差=-6.78；95%CI：-11.35，-2.22， = 0.004），但也能提高 2 型糖尿病患者的高密度脂蛋白胆固醇（HDL-C）水平（均差=1.53；95%CI：1.01，2.05， < 0.001）。然而，肉桂干预对空腹血糖、糖化血红蛋白（HbA1c）或总胆固醇（TC）水平无显著影响。我们发现，在非线性剂量-反应分析中，肉桂干预剂量对 TG 水平（-非线性=0.016）和 LDL-C 水平（-非线性=0.019）有显著影响。在亚组分析中，我们发现，肉桂剂量≤1200 mg 时有降血糖作用（均差=-11.1，95%CI：-14.64，-7.58， < 0.001）。（4）结论：肉桂干预可能有益于降低 TG 和 LDL-C 水平，同时提高 HDL-C 水平，干预剂量是影响 TG 和 LDL-C 水平的重要因素。
