Xu Cheng-Xiong, Jin Hua, Shin Ji-Young, Kim Ji-Eun, Cho Myung-Haing
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Front Biosci (Elite Ed). 2010 Jun 1;2(4):1472-84. doi: 10.2741/e206.
Lung cancer is the leading cause of cancer-related death worldwide and has frequently been associated with over-activated protein kinase B (PKB)/Akt. Akt is a serine/threonine protein kinase that plays an important role in cell growth, proliferation, and survival. Many lines of evidence point to the contribution of deregulated Akt in development or progression of lung cancer. In addition, recent studies have demonstrated that cancer cells defend themselves from therapeutic treatment through activation of pro-survival signals, including the Akt pathway. In this review, we described the way in which the Akt pathway is activated in development and progression of lung cancer, and the way in which deregulated Akt plays a significant role in lung tumorigenesis and resistance to chemo- or radiotherapy. In this review, we also discussed the potential of the Akt pathway as a target of lung cancer therapy.
肺癌是全球癌症相关死亡的主要原因，并且经常与蛋白激酶B（PKB）/Akt过度激活有关。Akt是一种丝氨酸/苏氨酸蛋白激酶，在细胞生长、增殖和存活中起重要作用。许多证据表明，Akt失调在肺癌的发生或发展中起作用。此外，最近的研究表明，癌细胞通过激活包括Akt途径在内的促生存信号来抵御治疗。在本综述中，我们描述了Akt途径在肺癌发生和发展中被激活的方式，以及失调的Akt在肺肿瘤发生和对化疗或放疗的耐药性中所起的重要作用。在本综述中，我们还讨论了Akt途径作为肺癌治疗靶点的潜力。
