Loza Matthew J, Penn Raymond B
Department of Medicine, Division of Pulmonary and Critical Care Medicine University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Front Biosci (Schol Ed). 2010 Jun 1;2(3):969-79. doi: 10.2741/s113.
It is widely recognized that Th2 cytokines derived from T cells play a major role in the development of allergic lung inflammation that causes most asthma. Beta-agonists are important rescue and maintenance therapies for asthma, yet our understanding of beta-agonist effects on T cell biology is surprisingly poor. Recent studies using both cell culture and more integrative models are beginning to reveal beta-agonist regulation of T cell signaling and function that may be important in the pathogenesis and treatment of asthma and possibly other inflammatory diseases. Here we provide a comprehensive review of the literature concerning beta-agonist effects on T cells, and discuss the relevance of emerging paradigms of beta-adrenergic receptor signaling to T cell function.
人们普遍认识到，源自T细胞的Th2细胞因子在导致大多数哮喘的过敏性肺部炎症的发展中起主要作用。β-激动剂是哮喘重要的急救和维持治疗药物，但我们对β-激动剂对T细胞生物学影响的了解却出奇地少。最近使用细胞培养和更综合模型的研究开始揭示β-激动剂对T细胞信号传导和功能的调节，这可能在哮喘以及可能的其他炎症性疾病的发病机制和治疗中具有重要意义。在此，我们对有关β-激动剂对T细胞影响的文献进行了全面综述，并讨论了β-肾上腺素能受体信号传导新范式与T细胞功能的相关性。
