Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, London, UK.
Arch Dis Child. 2011 Feb;96(2):192-4. doi: 10.1136/adc.2009.171975. Epub 2010 Jun 1.
To determine the incidence and examine the epidemiology of achalasia before the age of 16 years in the UK from 1998 to 2008.
25 regional paediatric surgery referral centres were asked to provide demographic and epidemiological data on cases of childhood achalasia from 1998 to 2008. Incidence rates were calculated from national population estimates. The data collection method was validated in one centre.
228 patients from 24 centres were diagnosed with achalasia before 16 years in the UK from 1998 to 2008. The mean incidence from 1998 to 2008 was 0.18/10(5) children/year. Where additional data was provided (69-81% of cases) 56% of children were male and the mean age of diagnosis was 10.9 years. Logistic regression analysis showed a rising incidence, with an OR of 1.12 (95% CI 1.06 to 1.16) for having achalasia in each successive year. The validation of this methodology showed that 95% of true cases and no false cases were identified.
The mean incidence of childhood achalasia in the UK from 1998 to 2008 is at least 0.18/10(5) children/year; this has risen over the last 11 years and compared to the only other study published in 1988.
确定英国在 1998 年至 2008 年期间 16 岁以下贲门失弛缓症的发病率并探讨其流行病学特征。
要求 25 个区域性儿科外科转诊中心提供 1998 年至 2008 年期间儿童贲门失弛缓症的人口统计学和流行病学数据。发病率根据全国人口估计数计算。在一个中心验证了数据收集方法。
1998 年至 2008 年期间，英国 24 个中心的 228 例患者在 16 岁之前被诊断为贲门失弛缓症。1998 年至 2008 年期间的平均发病率为 0.18/10(5)儿童/年。在提供了额外数据的情况下（69-81%的病例），56%的患儿为男性，诊断时的平均年龄为 10.9 岁。逻辑回归分析显示，发病率呈上升趋势，每年患病的几率比（OR）为 1.12（95%CI 1.06 至 1.16）。该方法学的验证表明，95%的真实病例和 0 例假阳性病例被识别出来。
1998 年至 2008 年期间，英国儿童贲门失弛缓症的平均发病率至少为 0.18/10(5)儿童/年；与 1988 年发表的唯一另一项研究相比，该发病率在过去 11 年中有所上升。
