Himizu M, Ishii K, Katagiri H, Saga K, Ono F, Yamamoto M, Todoroki T, Kawai Y, Watanabe K, Iri H
Department of Laboratory Medicine, Keio University, School of Medicine, Tokyo.
Rinsho Byori. 1991 Mar;39(3):302-8.
Determination of FDP D-dimer (D-dimer) has been recently developed for the diagnosis of thrombotic diseases with secondary fibrinolysis. We have studied the correlation between D-dimer and FDP-E concentrations in plasma from 282 patients with 630 samples. A linear correlation (r = 0.9269) was observed between the values of FDP-E and D-dimer. However, 13 out of 282 cases revealed an apparent dissociation of D-dimer concentrations from FDP-E values. Among them, 4 of these 13 cases (Group A) have shown to possess higher level of D-dimer when compared with the expected values from FDP-E, while 9 of 13 cases (Group B) revealed lower levels of D-dimer than that expected from FDP-E. All of Group A patients have been diagnosed as disseminated intravascular coagulation (DIC). On the other hand, in Group B patients, 6 of 9 were shown to have a widespread metastasis of cancer and 2 of them were under treatment with urokinase. To study whether Group B patients were under hypercoagulable or hyper-fibrinolytic state, we have examined ratios of AT III/alpha 2 PI and PIC/TAT in these cases. It has been shown that 4 of 9 patients in Group B have higher ratios of both AT III/alpha 2 PI and PIC/TAT if compared with other patients than Group B. This suggests that patients in Group B have been under hyper-fibrinolytic states.
FDP D - 二聚体（D - 二聚体）的检测最近已被用于诊断伴有继发性纤维蛋白溶解的血栓性疾病。我们对282例患者的630份血浆样本中D - 二聚体与FDP - E浓度之间的相关性进行了研究。FDP - E值与D - 二聚体之间观察到线性相关性（r = 0.9269）。然而，282例中有13例显示D - 二聚体浓度与FDP - E值明显解离。其中，这13例中的4例（A组）与FDP - E预期值相比显示D - 二聚体水平较高，而13例中的9例（B组）显示D - 二聚体水平低于FDP - E预期值。所有A组患者均被诊断为弥散性血管内凝血（DIC）。另一方面，在B组患者中，9例中有6例显示有广泛的癌症转移，其中2例正在接受尿激酶治疗。为研究B组患者处于高凝状态还是高纤溶状态，我们检测了这些病例中AT III/α2PI和PIC/TAT的比值。结果显示，与B组以外的其他患者相比，B组9例患者中有4例的AT III/α2PI和PIC/TAT比值均较高。这表明B组患者处于高纤溶状态。
