Takagi M, Wada H, Tanigawa M, Iwasaki E, Deguchi A, Mori Y, Suzuki H, Ohkubo I, Endou T, Deguchi K
2nd Department of Internal Medicine, Mie University School of Medicine, Tsu.
Rinsho Byori. 1990 Jul;38(7):806-12.
We measured FDP-D-dimer value in disseminated intravascular coagulation (DIC), pre-DIC (within 7 days before onset of DIC) and suspected DIC (not completely satisfying the DIC criteria). The level of FDP in many patients with pre-DIC was normal, but the level of FDP-D-dimer in most patients with pre-DIC was increased. FDP was markedly increased one day before onset of DIC but FDP-D-dimer was increased 7 days before the onset. FDP was significantly higher in DIC than in pre-DIC, but it was not higher in pre-DIC than in suspected DIC. In patients with hematological malignancies, FDP-D-dimer was statistically higher in DIC than in pre-DIC and in pre-DIC than in suspected DIC, but in non-hematological malignancies, FDP-D-dimer was not significantly different among the 3 groups. The peak increase of FDP-D-dimer was noted at a DIC score of 7 or 8. The correlation of FDP-D-dimer with FDP was better in pre-DIC than in DIC, and the ratio of FDP-D-dimer to FDP was higher in pre-DIC. FDP-D-dimer was not correlated with fibrinopeptide A or B beta 15-42 in pre-DIC. It is speculated that pre-DIC is a hypercoagulable state and FDP-D-dimer may be useful to the diagnosis of pre-DIC.
我们检测了弥散性血管内凝血（DIC）、DIC前期（DIC发病前7天内）及疑似DIC（未完全符合DIC标准）患者的纤维蛋白降解产物-D-二聚体（FDP-D-dimer）值。许多DIC前期患者的FDP水平正常，但大多数DIC前期患者的FDP-D-dimer水平升高。DIC发病前1天FDP显著升高，但FDP-D-dimer在发病前7天升高。DIC患者的FDP显著高于DIC前期患者，但DIC前期患者的FDP并不高于疑似DIC患者。血液系统恶性肿瘤患者中，DIC患者的FDP-D-dimer在统计学上高于DIC前期患者，DIC前期患者的FDP-D-dimer高于疑似DIC患者，但在非血液系统恶性肿瘤患者中，三组之间FDP-D-dimer无显著差异。FDP-D-dimer的峰值升高出现在DIC评分为7或8时。DIC前期FDP-D-dimer与FDP的相关性优于DIC，且DIC前期FDP-D-dimer与FDP的比值更高。DIC前期FDP-D-dimer与纤维蛋白肽A或Bβ15-42不相关。推测DIC前期是一种高凝状态，FDP-D-dimer可能对DIC前期的诊断有帮助。
