Fujimoto H, Kawamura T, Koizumi F, Ishimori A
Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine, Sendai.
Rinsho Byori. 1991 Apr;39(4):352-60.
Studies were performed on cancer detection and prevention in the high cancer risk group. To improve the screening method in the diagnosis of unspecified cancer, a modified combination assay was devised using a combination of several tumor markers and adding risk factors of malignancies obtainable from blood samples. Five tumor markers, AFP, CEA, CA 19-9, DUPAN-2 and CA 125 were determined simultaneously in each serum sample obtained from 54 patients with various cancer diseases. A modified combination assay was also examined using the risk factors of malignancies, pepsinogen I/II ratio together with 5 tumor markers. Detection rate was elevated to 68.5% by a combination assay using 5 tumor markers. Detection rate by modified combination assay using the risk factor (pepsinogen I/II ratio) together with 5 tumor markers was further improved to 88.8% without decreasing the specificity. The modified combination assay is easy in practice and expected to contribute in the screening of unspecified cancer diseases.
对癌症高危人群进行了癌症检测与预防研究。为改进未明确癌症诊断中的筛查方法，设计了一种改良联合检测法，该方法结合了几种肿瘤标志物，并加入了可从血样中获取的恶性肿瘤风险因素。对从54例患有各种癌症疾病的患者采集的每份血清样本，同时测定了5种肿瘤标志物，即甲胎蛋白（AFP）、癌胚抗原（CEA）、糖类抗原19-9（CA 19-9）、杜帕安-2（DUPAN-2）和糖类抗原125（CA 125）。还使用恶性肿瘤风险因素胃蛋白酶原I/II比值以及5种肿瘤标志物对改良联合检测法进行了检验。使用5种肿瘤标志物的联合检测法使检测率提高到了68.5%。使用风险因素（胃蛋白酶原I/II比值）以及5种肿瘤标志物的改良联合检测法在不降低特异性的情况下进一步提高到了88.8%。改良联合检测法在实际操作中简便易行，有望对未明确癌症疾病的筛查有所贡献。
