Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Osaka, Japan.
Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a004945. doi: 10.1101/cshperspect.a004945. Epub 2010 Apr 28.
Understanding the origin of life requires knowledge not only of the origin of biological molecules such as amino acids, nucleotides and their polymers, but also the manner in which those molecules are integrated into the organized systems that characterize cellular life. In this article, we introduce a constructive approach to understand how biological molecules can be arranged to achieve a higher-order biological function: replication of genetic information.
理解生命的起源不仅需要了解氨基酸、核苷酸及其聚合物等生物分子的起源,还需要了解这些分子是如何整合到构成细胞生命特征的有组织系统中的。在本文中,我们介绍了一种建设性的方法来理解生物分子如何排列以实现更高阶的生物学功能:遗传信息的复制。