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构建细胞的部分模型。

Constructing partial models of cells.

机构信息

Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Osaka, Japan.

出版信息

Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a004945. doi: 10.1101/cshperspect.a004945. Epub 2010 Apr 28.

Abstract

Understanding the origin of life requires knowledge not only of the origin of biological molecules such as amino acids, nucleotides and their polymers, but also the manner in which those molecules are integrated into the organized systems that characterize cellular life. In this article, we introduce a constructive approach to understand how biological molecules can be arranged to achieve a higher-order biological function: replication of genetic information.

摘要

理解生命的起源不仅需要了解氨基酸、核苷酸及其聚合物等生物分子的起源,还需要了解这些分子是如何整合到构成细胞生命特征的有组织系统中的。在本文中,我们介绍了一种建设性的方法来理解生物分子如何排列以实现更高阶的生物学功能:遗传信息的复制。

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引用本文的文献

本文引用的文献

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Self-sustained replication of an RNA enzyme.一种RNA酶的自我维持复制
Science. 2009 Feb 27;323(5918):1229-32. doi: 10.1126/science.1167856. Epub 2009 Jan 8.
5
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Philos Trans R Soc Lond B Biol Sci. 2007 Oct 29;362(1486):1741-50. doi: 10.1098/rstb.2007.2066.
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Femtoliter compartment in liposomes for in vitro selection of proteins.用于蛋白质体外筛选的脂质体中的飞升隔室。
Anal Biochem. 2006 Oct 1;357(1):128-36. doi: 10.1016/j.ab.2006.06.040. Epub 2006 Jul 18.
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Synthetic biology.合成生物学
Nat Rev Genet. 2005 Jul;6(7):533-43. doi: 10.1038/nrg1637.
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A giant step towards artificial life?迈向人造生命的巨大一步?
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