Yamagiwa H
Department of Clinical Pathology, Mie University School of Medicine, Tsu.
Rinsho Byori. 1991 Apr;39(4):421-4.
A histopathological study was performed on 53 radiated and 123 non-radiated resected esophageal cancers. The preoperatively radiated (3,000 to 4,000 rads) lesions were usually smaller than the non-treated ones due to the reduction in tumor tissue, and the incidence of infiltrative ulcerated type lesions (Borrmann 3-like) was markedly higher in the former. Histologically, the incidence of moderately-differentiated squamous cell carcinoma (SCC) was lower and that of well-differentiated SCC was higher in the radiated cases, probably due to the high sensitivity of the former type compared with the latter. The incidence of vascular involvement was lower in the radiated cases than the non-treated cases because of the reduction in vessel size due to fibrosis and scar caused by the radiation. However, lymph-nodal metastasis was more frequent in the radiated cases in which the more deeply invaded lesions were included compared with the non-treated cases.
对53例接受过放疗的食管癌切除标本和123例未接受过放疗的食管癌切除标本进行了组织病理学研究。术前接受过放疗（3000至4000拉德）的病变通常因肿瘤组织减少而比未接受治疗的病变小，且前者浸润性溃疡型病变（类似Borrmann 3型）的发生率明显更高。组织学上，放疗病例中中分化鳞状细胞癌（SCC）的发生率较低，高分化SCC的发生率较高，这可能是因为前一种类型比后一种类型对放疗更敏感。由于放疗导致的纤维化和瘢痕使血管尺寸减小，放疗病例中血管受累的发生率低于未接受治疗的病例。然而，与未接受治疗的病例相比，在包含浸润更深病变的放疗病例中，淋巴结转移更为常见。
