Dissecting the complex physiology of endothelin: new lessons from genetic models.
作者信息
Pollock David M
出版信息
Hypertension. 2010 Jul;56(1):31-3. doi: 10.1161/HYPERTENSIONAHA.109.139758. Epub 2010 Jun 1.
Abstract
摘要
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Dissecting the complex physiology of endothelin: new lessons from genetic models.剖析内皮素的复杂生理学：遗传模型带来的新启示。
Hypertension. 2010 Jul;56(1):31-3. doi: 10.1161/HYPERTENSIONAHA.109.139758. Epub 2010 Jun 1.
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Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle endothelin receptors.内皮素 B 受体介导的血管内皮预防脑血管重构在糖尿病中减弱，原因是平滑肌内皮素受体上调。
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本文引用的文献
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Low blood pressure in endothelial cell-specific endothelin 1 knockout mice.内皮细胞特异性内皮素 1 敲除小鼠的低血压。
Hypertension. 2010 Jul;56(1):121-8. doi: 10.1161/HYPERTENSIONAHA.109.138701. Epub 2010 Jun 1.
2
Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice.盐负荷和内皮细胞特异性内皮素-1过表达对小鼠血压和血管功能的有害协同作用。
J Hypertens. 2010 Jun;28(6):1243-51. doi: 10.1097/HJH.0b013e328338bb8b.
3
Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells.在内皮细胞中过表达内皮素-1的转基因小鼠模型中，无血压升高情况下的血管炎症。
J Hypertens. 2008 Jun;26(6):1102-9. doi: 10.1097/HJH.0b013e3282fc2184.
4
The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?内皮素系统作为心血管疾病的治疗靶点：厚望还是空想？
Br J Pharmacol. 2008 Mar;153(6):1105-19. doi: 10.1038/sj.bjp.0707516. Epub 2007 Oct 29.
5
Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease.内皮素ET(A)和ET(B)受体在心血管疾病中的相反作用。
Annu Rev Pharmacol Toxicol. 2007;47:731-59. doi: 10.1146/annurev.pharmtox.47.120505.105134.
6
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention.内皮素B受体在集合管特异性敲除会导致高血压和钠潴留。
Am J Physiol Renal Physiol. 2006 Dec;291(6):F1274-80. doi: 10.1152/ajprenal.00190.2006. Epub 2006 Jul 25.
7
Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt.内皮细胞内皮素B受体的缺失不影响血压或对盐的敏感性。
Hypertension. 2006 Aug;48(2):286-93. doi: 10.1161/01.HYP.0000229907.58470.4c. Epub 2006 Jun 26.
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NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1.NADPH氧化酶抑制可减轻氧化应激，但不能减轻慢性ET-1所导致的高血压。
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Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction.人内皮素-1在内皮细胞中的特异性过表达会导致血管重塑和内皮功能障碍。
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Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention.内皮素-1在集合管特异性敲除会导致高血压和钠潴留。
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