Nakajima K, Taki J, Bunko H, Muramori A, Matunari I, Konishi K, Hisada K, Ichihara T
Department of Nuclear Medicine, Kanazawa University.
Kaku Igaku. 1991 Feb;28(2):127-33.
The early dynamic change of a new myocardial imaging agent, 99mTc-SQ30217, was investigated in SPECT study. A three-headed high sensitivity SPECT system was employed to evaluate the serial changes of accumulation pattern in the heart, lung and liver using a "continuous repetitive acquisition" mode. The myocardial activity reached a peak rapidly and decreased with rapid clearance rate. The analysis of myocardial clearance curve showed a T1/2 of 2.8 minutes (k1 = 0.25 +/- 0.12/min) in the rapid phase, and a T1/2 of 57 minutes (k2 = 0.012 +/- 0.011/min) in the slow phase. The tracer clearance in the lung was more rapid, while the hepatic uptake reached a peak approximately 10 to 15 minutes after injection. When the serial SPECT images were reviewed, the early 3-minute acquisition within 10 minutes after injection showed better image quality than the images obtained after 10 minutes. The hepatic activity did not obscure the infero-septal wall in the earlier images, but did in the images 10 minutes after injection. Thus, quick SPECT data acquisition seemed to be desirable for this agent. We concluded that 99mTc-SQ30217 was a promising radiopharmaceutical for myocardial perfusion imaging.
在单光子发射计算机断层显像（SPECT）研究中，对新型心肌显像剂99mTc-SQ30217的早期动态变化进行了研究。采用三头高灵敏度SPECT系统，以“连续重复采集”模式评估心脏、肺和肝脏中放射性药物蓄积模式的系列变化。心肌放射性活度迅速达到峰值，并以较快的清除率下降。心肌清除曲线分析显示，快速相的半衰期为2.8分钟（k1 = 0.25±0.12/分钟），缓慢相的半衰期为57分钟（k2 = 0.012±0.011/分钟）。肺部的示踪剂清除更快，而肝脏摄取在注射后约10至15分钟达到峰值。回顾系列SPECT图像时，注射后10分钟内的早期3分钟采集图像质量优于10分钟后获得的图像。早期图像中肝脏放射性活度未遮盖下壁和前间隔壁，但注射后10分钟的图像中则遮盖了。因此，对于这种显像剂，似乎需要快速进行SPECT数据采集。我们得出结论，99mTc-SQ30217是一种有前景的用于心肌灌注显像的放射性药物。
