Tenta R, Panagiotakos D B, Fragopoulou E, Nomikos T, Pitsavos C, Chrysohoou C, Antonopoulou S, Stefanadis C
Department of Nutrition Science-Dietetics, Harokopio University, Athens, Greece.
J Musculoskelet Neuronal Interact. 2010 Jun;10(2):174-9.
We investigated the relationship between the major bone turnover markers, i.e., Osteoprotegerin (OPG) and Receptor activator of nuclear factor-kappaB ligand (RANKL) and serum adipokines (leptin, adiponectin) levels in a sample of apparently healthy women.
A random sample which consisted of 80 females (18-71 years) was studied. Elisa method was used to measure the OPG, RANKL and the leptin, adiponectin levels in females' serum.
OPG values were inversely correlated with leptin (rho = -0.38, p = 0.002) and positively correlated with age (rho = 0.27, p=0.01) and body mass index (rho = 0.29, p=0.009). RANKL values were inversely correlated with adiponectin (rho = -0.23, p = 0.06) and age (rho = -0.30, p=0.01). Additionally, OPG was higher in post- as compared to pre-menopausal women. Further data analysis adjusting for potential confounders revealed that the OPG/RANKL ratio was positively associated with adiponectin and inversely associated with leptin levels independent of the effect of age, body mass index and menopausal status.
These results reveal that leptin circulating levels are inversely associated with serum OPG/RANKL ratio among healthy women.
我们在一组看似健康的女性样本中，研究了主要骨转换标志物，即骨保护素（OPG）和核因子κB受体活化因子配体（RANKL）与血清脂肪因子（瘦素、脂联素）水平之间的关系。
对一个由80名女性（18 - 71岁）组成的随机样本进行了研究。采用酶联免疫吸附测定（ELISA）法测量女性血清中的OPG、RANKL以及瘦素、脂联素水平。
OPG值与瘦素呈负相关（rho = -0.38，p = 0.002），与年龄呈正相关（rho = 0.27，p = 0.01），与体重指数呈正相关（rho = 0.29，p = 0.009）。RANKL值与脂联素呈负相关（rho = -0.23，p = 0.06），与年龄呈负相关（rho = -0.30，p = 0.01）。此外，绝经后女性的OPG水平高于绝经前女性。对潜在混杂因素进行校正后的进一步数据分析显示，独立于年龄、体重指数和绝经状态的影响，OPG/RANKL比值与脂联素呈正相关，与瘦素水平呈负相关。
这些结果表明，在健康女性中，循环瘦素水平与血清OPG/RANKL比值呈负相关。
