Kavaliauskiene Sandra, Povilionyte Romualda, Jakubovskiene Jūrate, Jasaitiene Daiva, Valiukeviciene Skaidra, Petrauskiene Renata, Zarankiene Rūta Paulina, Skrodeniene Erika, Vitkauskiene Astra
Department of Skin and Venereal Diseases, Kaunas University of Medicine, Lithuania.
Medicina (Kaunas). 2010;46(3):180-4.
The aim of the study was to determine the incidence of onychomycosis in affected nails among psoriatic and nonpsoriatic patients.
The study included 559 patients (168 males and 391 females) examined for fungal infection of nails using direct microscopy and culture tests.
Of the 559 patients, 30 (5.3%) (9 males and 21 females) had psoriasis. The incidence of onychomycosis (determined according to positive results of culture tests) among psoriatic patients was 23.3% (7/30) as compared to 23.6% (125/529) among nonpsoriatic patients (P>0.05). Among psoriatic patients, dermatophytes were detected in 5 (71.4%) of the 7 cases, and in the remaining 2 cases, yeast and yeast-like fungi were found. Among nonpsoriatic patients, dermatophytes, yeast, and mould were detected in 66, 43, and 16 cases of the 125 positive cultures, respectively. The sensitivity of the microscopic examination versus culture for the identified dermatophytes and yeasts was 87.3% and 18.6%, accordingly.
There was no difference in the incidence of onychomycosis and distribution of fungal infections among psoriatic and nonpsoriatic patients. Onychomycosis was detected in less than one-third of the patients with clinically affected nails. The culture test is an important tool in diagnosing onychomycosis and selecting systemic treatment.
本研究的目的是确定银屑病患者和非银屑病患者患甲真菌病的患甲发生率。
本研究纳入了559例患者(168例男性和391例女性),采用直接显微镜检查和培养试验检测指甲真菌感染情况。
559例患者中,30例(5.3%)(9例男性和21例女性)患有银屑病。银屑病患者中甲真菌病的发生率(根据培养试验阳性结果确定)为23.3%(7/30),而非银屑病患者为23.6%(125/529)(P>0.05)。在银屑病患者中,7例中有5例(71.4%)检测到皮肤癣菌,其余2例发现酵母菌和酵母样真菌。在非银屑病患者中,125例阳性培养物中分别有66例、43例和16例检测到皮肤癣菌、酵母菌和霉菌。对于已鉴定的皮肤癣菌和酵母菌,显微镜检查相对于培养的敏感性分别为87.3%和18.6%。
银屑病患者和非银屑病患者中甲真菌病的发生率及真菌感染的分布没有差异。临床上有指甲受累的患者中,不到三分之一检测到甲真菌病。培养试验是诊断甲真菌病和选择全身治疗的重要工具。