Caballero Plasencia A M, López Callejas C, Valenzuela Barranco M, Montero García M, Muros Navarro M C, de los Reyes García M C, Sánchez Martínez H, Bellot García V
Unidad de Hepatologia, Hospital Universitario de Granada.
Med Clin (Barc). 1991 Apr 6;96(13):481-5.
The epidemiology of primary biliary cirrhosis (PBC) in Spain is still poorly known. In fact, remarkable differences between areas have been found.
The epidemiology of PBC was investigated in the South area of the city and the province of Granada from 1976 through 1989. Several clinical and epidemiological data were collected from 25 patients who met the criteria for PBC and the yearly incidence and prevalence were calculated.
The ages of patients which PBC ranged from 31 to 74 years (mean age 50 +/- 10.5); 88% were females and 28% were diagnosed in the asymptomatic phase of the disease. The incidence for the study period was variable, with a maximum of 6.8 cases/million and an overall yearly incidence rate of 4.1 +/- 2.3 cases/million (7.1 +/- 4.3 cases/million for females). When the risk population was considered (people over 25 years) the respective values were 11.5 and 6.9 +/- 3.7 cases/million (12.1 +/- 7.2 cases/million for females). The prevalence showed a progressive increase, being 36.4 cases/million at the end of the study; for the "risk" population it was 61.5/million (100 cases/million for females).
Incidence and prevalence of PBC in the area of study are within medium and medium-high values for Spain and Europe. As in other studies, personal environmental or social factors with epidemiological significance were not identified.
西班牙原发性胆汁性肝硬化（PBC）的流行病学情况仍鲜为人知。事实上，已发现不同地区存在显著差异。
对1976年至1989年格拉纳达市南部地区和省份的PBC流行病学情况进行调查。收集了25例符合PBC标准患者的多项临床和流行病学数据，并计算了年发病率和患病率。
PBC患者年龄在31至74岁之间（平均年龄50±10.5岁）；88%为女性，28%在疾病无症状阶段被诊断。研究期间发病率有所变化，最高为6.8例/百万，总体年发病率为4.1±2.3例/百万（女性为7.1±4.3例/百万）。若考虑风险人群（25岁以上人群），相应数值分别为11.5例/百万和6.9±3.7例/百万（女性为12.1±7.2例/百万）。患病率呈逐渐上升趋势，研究结束时为36.4例/百万；“风险”人群患病率为61.5例/百万（女性为100例/百万）。
研究区域内PBC的发病率和患病率处于西班牙和欧洲的中等及中高值范围内。与其他研究一样，未发现具有流行病学意义的个人环境或社会因素。
