Moreno Sánchez D, Cassinello Ogea C, González Blanco P, Pulido Ortega F, Castellano Tortajada G
Servicio de Aparato Digestivo, Hospital 12 de Octubre, Madrid.
Med Clin (Barc). 1990 Apr 21;94(15):564-9.
This study reports the epidemiologic features of primary biliary cirrhosis in patients admitted to the 12 de Octubre Hospital in Madrid between 1974 and 1988. Among the 54 patients recruited, 45 lived in the hospital surroundings. Ninety-three percent were women with a mean age of 53.7 +/- 15.1 years (range 25 to 76 years). The maximal incidence of the disorder occurred in patients above 60 years. At the time of diagnosis 37.8% were asymptomatic and the mean time to symptoms was 20.1 +/- 18.1 months. The year incidence was maximal in 1982, being the mean year rate of 7.45 +/- 4.9 cases/10(6) inhabitants. This rate was lower in women above 25 years (13.9 +/- 8 cases/10(6) inh/yr). A comparable incidence has been reported in Catalonia and Asturias but it was higher in Navarre. During the study period the prevalence of the illness has increased. By december 1988 the mean incidence for the whole group was 45.5 cases/10(6) inh/yr, whereas it reached 134.1 cases/10(6) ihn/yr in women above 25 years. Environmental, genetic or personal factors contributing to the development of the illness have not been encountered. There was, however, a relationship between the mortality and morbidity rates with the severity of the symptoms and with the degree of histological damage.
本研究报告了1974年至1988年间马德里10月12日医院收治的原发性胆汁性肝硬化患者的流行病学特征。在招募的54例患者中，45例居住在医院周边地区。93%为女性，平均年龄53.7±15.1岁（范围25至76岁）。该疾病的最高发病率出现在60岁以上的患者中。诊断时37.8%的患者无症状，出现症状的平均时间为20.1±18.1个月。年发病率在1982年最高，平均年发病率为7.45±4.9例/10⁶居民。25岁以上女性的发病率较低（13.9±8例/10⁶居民/年）。加泰罗尼亚和阿斯图里亚斯也报告了类似的发病率，但纳瓦拉的发病率更高。在研究期间，该疾病的患病率有所上升。到1988年12月，整个组的平均发病率为45.5例/10⁶居民/年，而25岁以上女性的发病率达到134.1例/10⁶居民/年。尚未发现导致该疾病发生的环境、遗传或个人因素。然而，死亡率和发病率与症状严重程度以及组织学损伤程度之间存在关联。
