Wauters Carla A P, Kooistra Bauke W, de Kievit-van der Heijden Ineke M, Strobbe Luc J A
Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.
Acta Cytol. 2010 May-Jun;54(3):259-64. doi: 10.1159/000325032.
To determine the value of cytology in the workup of male breast lesions, important for the management in a same-day breast clinic.
A total of 146 fine needle aspirations (FNAs) from the male breast were classified in the categories malignant, suspicious, atypical, benign and inadequate. Cytohistologic correlation was done.
Histologic correlation was available in 85 cases. On FNA the 15 malignant cases were classified as malignant (n = 11), suspicious for malignancy (n = 2) or atypical (n = 2). Of the 35 benign lesions on histology 3 cases were classified as atypia and 1 as suspicious for malignancy on FNA. In the inadequate FNAs (n = 45), the corresponding histologic specimens were benign, no carcinomas were diagnosed. The sensitivity and specificity of the FNA compared to the definite resection diagnosis were 100% and 90.2%, respectively. The results were comparable with the outcomes of the reviewed studies on male breast lesions in the recent literature.
Based on the nature of the benign breast lesions in man, a substantial number of inadequate FNAs were obtained. However, due to the good cytohistologic correlations in the group of malignant lesions, we can conclude that cytology remains an important diagnostic tool in the initial workup of male breast carcinomas.
确定细胞学检查在男性乳腺病变检查中的价值，这对当日乳腺门诊的管理很重要。
对146例男性乳腺细针穿刺抽吸（FNA）样本进行分类，分为恶性、可疑、非典型、良性和不充分五类。进行了细胞组织学相关性分析。
85例有组织学相关性分析结果。FNA检查时，15例恶性病例被分类为恶性（n = 11）、可疑恶性（n = 2）或非典型（n = 2）。组织学检查为良性的35例病变中，FNA检查有3例被分类为非典型，1例可疑恶性。在不充分的FNA样本（n = 45）中，相应的组织学标本为良性，未诊断出癌症。与明确的切除诊断相比，FNA检查的敏感性和特异性分别为100%和90.2%。结果与近期文献中关于男性乳腺病变的回顾性研究结果相当。
基于男性乳腺良性病变的性质，获得了大量不充分的FNA样本。然而，由于恶性病变组中良好的细胞组织学相关性，我们可以得出结论，细胞学检查仍然是男性乳腺癌初始检查中的一项重要诊断工具。
