对选择性 PI3 激酶抑制剂 liphagal 的对映选择性全合成。
Enantioselective total synthesis of the selective PI3 kinase inhibitor liphagal.
机构信息
Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, 18071 Granada, Spain.
出版信息
Org Lett. 2010 Oct 15;12(20):4450-3. doi: 10.1021/ol101173w.
PMID:20518529
Abstract
The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K α isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic "liphagane" skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.
摘要
已实现了从海洋海绵 Aka coralliphaga 中分离出的选择性 PI3Kα抑制剂 liphagal 的对映选择性全合成。新型四环“liphagane”骨架在阳离子树脂存在下通过二羟二氢紫堇烷酚苄基醚的氢化一步形成。
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