利法加（Liphagal），一种从海绵阿卡罗珊瑚（akacoralliphaga）中分离出的PI3激酶α选择性抑制剂：结构解析与仿生合成。

Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis.

作者信息

Marion Frederic, Williams David E, Patrick Brian O, Hollander Irwin, Mallon Robert, Kim Steven C, Roll Deborah M, Feldberg Larry, Van Soest Rob, Andersen Raymond J

机构信息

Department of Chemistry, University of British Columbia, Vancouver, Canada.

出版信息

Org Lett. 2006 Jan 19;8(2):321-4. doi: 10.1021/ol052744t.

DOI:10.1021/ol052744t

PMID:16408905

Abstract

[structure: see text] Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the constitution of liphagal (1) and support a proposed biogenesis.

摘要

[结构：见正文] 利法加尔（1）是一种PI3Kα的选择性抑制剂，它是从在多米尼克采集的海洋海绵阿卡珊瑚海绵中分离出来的。利法加尔（1）的“利法烷”半萜类碳骨架是新的。已采用仿生全合成来确认利法加尔（1）的结构并支持提出的生物合成途径。