设计、合成与结构分析 D,L-混合聚吡咯烷酮。1. 从非肽类肽模拟物到纳米管。
Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 1. From nonpeptide peptidomimetics to nanotubes.
机构信息
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
Org Lett. 2010 Jul 2;12(13):2990-3. doi: 10.1021/ol101007n.
Abstract
To expand the potential conformational space available to the polypyrroline structural motif, an open chain, D,L-alternating hexapyrrolinone was designed and synthesized. Structural studies, including solution NMR and X-ray crystallographic analysis, revealed that the hexapyrrolinone adopts a turn conformation both in solution and in the solid state, with aggregation in solution and a nanotube-like quaternary structure in the crystal.
摘要
为了拓展聚吡咯啉结构模体的潜在构象空间，设计并合成了一种开链的、D,L-交替的六吡咯啉酮。结构研究包括溶液 NMR 和 X 射线晶体学分析表明，六吡咯啉酮在溶液中和固态中均采取了一个转折构象，在溶液中聚集，在晶体中形成纳米管状的四级结构。
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