Padmini S, Rao P S
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad.
Lipids. 1991 Jan;26(1):83-5. doi: 10.1007/BF02544031.
Food restriction was found to impair the incorporation of [1-14C]palmitate into myelin membrane lipids of developing rat brain. An attempt was made to determine whether this phenomenon is due to differences in the rate of utilization of the labelled precursor or to its enhanced degradation via beta-oxidative pathways. Undernutrition in pups was imposed by food restriction during gestation and lactation. beta-Oxidation by brain region homogenates using [1-14C]palmitate was monitored at days 7, 14 and 21 of postnatal age. There was a significant increase in beta-oxidation in the brain regions of undernourished pups, with the cerebrum and cerebellum being more affected than the brain stem. Because developing brain possesses the enzymic potential to utilize ketone bodies, the data may indicate increased usage of palmitate as an energy source in the developing brain of undernourished animals.
研究发现，食物限制会损害[1-14C]棕榈酸酯掺入发育中大鼠脑髓磷脂膜脂质的过程。研究人员试图确定这种现象是由于标记前体的利用率不同，还是由于其通过β-氧化途径的降解增强所致。在妊娠和哺乳期通过食物限制使幼崽营养不良。在出生后第7、14和21天监测使用[1-14C]棕榈酸酯的脑区匀浆的β-氧化情况。营养不良幼崽的脑区β-氧化显著增加，大脑和小脑比脑干受影响更大。由于发育中的大脑具有利用酮体的酶潜力，这些数据可能表明营养不良动物发育中的大脑中棕榈酸酯作为能量来源的使用增加。
