从自组装囊泡到原始细胞。
From self-assembled vesicles to protocells.
机构信息
FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002170. doi: 10.1101/cshperspect.a002170. Epub 2010 Jun 2.
Abstract
Self-assembled vesicles are essential components of primitive cells. We review the importance of vesicles during the origins of life, fundamental thermodynamics and kinetics of self-assembly, and experimental models of simple vesicles, focusing on prebiotically plausible fatty acids and their derivatives. We review recent work on interactions of simple vesicles with RNA and other studies of the transition from vesicles to protocells. Finally we discuss current challenges in understanding the biophysics of protocells, as well as conceptual questions in information transmission and self-replication.
摘要
自组装囊泡是原始细胞的重要组成部分。我们回顾了囊泡在生命起源、自组装的基本热力学和动力学以及简单囊泡的实验模型中的重要性，重点关注了在生命起源前可能存在的脂肪酸及其衍生物。我们回顾了近期关于简单囊泡与 RNA 相互作用的研究以及其他关于从囊泡到原细胞转变的研究。最后，我们讨论了当前理解原细胞生物物理学的挑战，以及信息传递和自我复制的概念问题。
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