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在两名患有严重发热疾病的患者中检测到“Candidatus Neoehrlichia mikurensis”：欧洲序列变异的证据。

Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant.

机构信息

Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.

出版信息

J Clin Microbiol. 2010 Jul;48(7):2630-5. doi: 10.1128/JCM.00588-10. Epub 2010 Jun 2.

DOI:10.1128/JCM.00588-10
PMID:20519481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2897504/
Abstract

Recently, a new genus of Anaplasmataceae termed "Candidatus Neoehrlichia" was discovered in ticks and rodents. Here, we report on two patients who suffered from febrile bacteremia due to "Candidatus Neoehrlichia mikurensis" associated with thrombotic or hemorrhagic events. 16S rRNA and groEL gene sequencing provided evidence of three groups of sequence variants.

摘要

最近，在蜱虫和啮齿动物中发现了一个新的立克次体科属，称为“候选新立克次体”。在这里，我们报告了两名因“候选新立克次体 mikurensis”引起的发热性菌血症患者，伴有血栓形成或出血事件。16S rRNA 和 groEL 基因测序提供了三组序列变异的证据。

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本文引用的文献

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First case of human "Candidatus Neoehrlichia mikurensis" infection in a febrile patient with chronic lymphocytic leukemia.首例发热慢性淋巴细胞白血病患者感染“Candidatus Neoehrlichia mikurensis”。
J Clin Microbiol. 2010 May;48(5):1956-9. doi: 10.1128/JCM.02423-09. Epub 2010 Mar 10.
2
Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis.持续性感染有助于产生针对致命埃立克体病的异源保护性免疫。
Infect Immun. 2009 Dec;77(12):5682-9. doi: 10.1128/IAI.00720-09. Epub 2009 Oct 5.
3
Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis.使用基于商业通用16S rRNA基因的聚合酶链反应（PCR）和序列分析对全血样本中的菌血症进行诊断。
J Clin Microbiol. 2009 Sep;47(9):2759-65. doi: 10.1128/JCM.00567-09. Epub 2009 Jul 1.
4
Ixodes ovatus Ehrlichia exhibits unique ultrastructural characteristics in mammalian endothelial and tick-derived cells.卵形硬蜱埃立克体在哺乳动物内皮细胞和蜱源细胞中表现出独特的超微结构特征。
Ann N Y Acad Sci. 2009 May;1166:112-9. doi: 10.1111/j.1749-6632.2009.04520.x.
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Infection by Wolbachia: from passengers to residents.沃尔巴克氏体感染：从过客到定居者。
C R Biol. 2009 Feb-Mar;332(2-3):284-97. doi: 10.1016/j.crvi.2008.09.010. Epub 2008 Dec 2.
6
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The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.嗜吞噬细胞无形体的清除需要CD4 + T细胞，但独立于Th1细胞因子和广泛的效应机制。
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T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection.非T细胞依赖的体液免疫足以抵御致死性细胞内埃立克体感染。
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