在两名患有严重发热疾病的患者中检测到“Candidatus Neoehrlichia mikurensis”：欧洲序列变异的证据。
Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant.
机构信息
Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
出版信息
J Clin Microbiol. 2010 Jul;48(7):2630-5. doi: 10.1128/JCM.00588-10. Epub 2010 Jun 2.
Abstract
Recently, a new genus of Anaplasmataceae termed "Candidatus Neoehrlichia" was discovered in ticks and rodents. Here, we report on two patients who suffered from febrile bacteremia due to "Candidatus Neoehrlichia mikurensis" associated with thrombotic or hemorrhagic events. 16S rRNA and groEL gene sequencing provided evidence of three groups of sequence variants.
摘要
最近，在蜱虫和啮齿动物中发现了一个新的立克次体科属，称为“候选新立克次体”。在这里，我们报告了两名因“候选新立克次体 mikurensis”引起的发热性菌血症患者，伴有血栓形成或出血事件。16S rRNA 和 groEL 基因测序提供了三组序列变异的证据。
相似文献
1
Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant.在两名患有严重发热疾病的患者中检测到“Candidatus Neoehrlichia mikurensis”：欧洲序列变异的证据。
J Clin Microbiol. 2010 Jul;48(7):2630-5. doi: 10.1128/JCM.00588-10. Epub 2010 Jun 2.
2
Case report: first symptomatic Candidatus Neoehrlichia mikurensis infection in Slovenia.病例报告：斯洛文尼亚首例有症状的候选新立克次体感染。
BMC Infect Dis. 2021 Jun 15;21(1):579. doi: 10.1186/s12879-021-06297-z.
3
First case of human "Candidatus Neoehrlichia mikurensis" infection in a febrile patient with chronic lymphocytic leukemia.首例发热慢性淋巴细胞白血病患者感染“Candidatus Neoehrlichia mikurensis”。
J Clin Microbiol. 2010 May;48(5):1956-9. doi: 10.1128/JCM.02423-09. Epub 2010 Mar 10.
4
Close geographic association of human neoehrlichiosis and tick populations carrying "Candidatus Neoehrlichia mikurensis" in eastern Switzerland.在瑞士东部，人类新型埃立克体病与携带“候选新立克次体”的蜱种群的地理关联性非常密切。
J Clin Microbiol. 2013 Jan;51(1):169-76. doi: 10.1128/JCM.01955-12. Epub 2012 Oct 31.
5
"Candidatus Neoehrlichia mikurensis" infection in a dog from Germany.德国一犬感染“候选新立克次体”。
J Clin Microbiol. 2011 May;49(5):2059-62. doi: 10.1128/JCM.02327-10. Epub 2011 Mar 2.
6
First detection of tick-borne "Candidatus Neoehrlichia mikurensis" in Denmark 2011.2011 年丹麦首次检出蜱传“候选新立克次体”。
Euro Surveill. 2012 Feb 23;17(8):20096.
7
"Candidatus Neoehrlichia chilensis" sp. nov.: Molecular detection and characterization of a novel Anaplasmataceae in wild rodents from Valdivia, southern Chile."Candidatus Neoehrlichia chilensis" sp. nov.：智利南部瓦尔迪维亚野生啮齿动物中新的无形体科的分子检测与特征描述。
Transbound Emerg Dis. 2018 Apr;65(2):357-362. doi: 10.1111/tbed.12815. Epub 2018 Jan 24.
8
Neoehrlichiosis - a new tick-borne disease - is there a threat in Poland?新埃立克体病——一种新的蜱传疾病——在波兰构成威胁吗？
Przegl Epidemiol. 2015;69(1):23-6, 131-3.
9
Infections with the tick-borne bacterium "Candidatus Neoehrlichia mikurensis" mimic noninfectious conditions in patients with B cell malignancies or autoimmune diseases.感染蜱传播的细菌“Candidatus Neoehrlichia mikurensis”会使 B 细胞恶性肿瘤或自身免疫性疾病患者出现非传染性症状。
Clin Infect Dis. 2014 Jun;58(12):1716-22. doi: 10.1093/cid/ciu189. Epub 2014 Mar 18.
10
Presence of Candidatus Neoehrlichia mikurensis and Babesia microti in rodents and two tick species (Ixodes ricinus and Ixodes trianguliceps) in Slovakia.斯洛伐克啮齿动物以及两种蜱虫（蓖麻硬蜱和三角头硬蜱）中新型埃立克体属米库伦斯种和微小巴贝斯虫的存在情况。
Ticks Tick Borne Dis. 2016 Mar;7(2):319-26. doi: 10.1016/j.ttbdis.2015.11.008. Epub 2015 Nov 26.
引用本文的文献
1
Dynamics of and associated bacterial pathogens in the forest and agricultural ecosystems of northeastern France.法国东北部森林和农业生态系统中的[具体内容缺失]及其相关细菌病原体的动态变化
Appl Environ Microbiol. 2025 Jun 18;91(6):e0079325. doi: 10.1128/aem.00793-25. Epub 2025 May 29.
2
Ten years of detecting Neoehrlichia mikurensis infections in Sweden: demographic, clinical and inflammatory parameters.在瑞典检测新立克次体感染的十年：人口统计学、临床和炎症参数。
Eur J Clin Microbiol Infect Dis. 2024 Nov;43(11):2083-2092. doi: 10.1007/s10096-024-04909-5. Epub 2024 Aug 13.
3
Candidatus Neoehrlichia mikurensis Infection in Patient with Antecedent Hematologic Neoplasm, Spain.西班牙一例血液系统恶性肿瘤患者感染候选嗜吞噬细胞无形体
Emerg Infect Dis. 2023 Aug;29(8):1659-1662. doi: 10.3201/eid2908.230428.
4
Fever of Unknown Origin, a Vascular Event, and Immunosuppression in Tick-Endemic Areas: Think About Neoehrlichiosis.蜱虫流行地区不明原因发热、血管事件与免疫抑制：考虑新埃立克体病。
Cureus. 2023 Jun 19;15(6):e40617. doi: 10.7759/cureus.40617. eCollection 2023 Jun.
5
-A New Emerging Tick-Borne Pathogen in North-Eastern Poland?波兰东北部一种新出现的蜱传病原体？
Pathogens. 2023 Feb 12;12(2):307. doi: 10.3390/pathogens12020307.
6
Revealing the Tick Microbiome: Insights into Midgut and Salivary Gland Microbiota of Female Ticks.揭示 tick 微生物组：雌性 tick 中肠和唾液腺微生物组的新见解。
Int J Mol Sci. 2023 Jan 6;24(2):1100. doi: 10.3390/ijms24021100.
7
Prevalence of Bacterial and Protozoan Pathogens in Ticks Collected from Birds in the Republic of Moldova.摩尔多瓦共和国鸟类身上采集的蜱中细菌和原生动物病原体的患病率
Microorganisms. 2022 May 27;10(6):1111. doi: 10.3390/microorganisms10061111.
8
Cytokine responses of immunosuppressed and immunocompetent patients with Neoehrlichia mikurensis infection.免疫抑制和免疫功能正常的新立克次体感染患者的细胞因子反应。
Med Microbiol Immunol. 2022 Jun;211(2-3):133-141. doi: 10.1007/s00430-022-00737-6. Epub 2022 Apr 17.
9
Clinical Aspects and Detection of Emerging Rickettsial Pathogens: A "One Health" Approach Study in Serbia, 2020.新兴立克次体病原体的临床特征与检测：2020年塞尔维亚的一项“同一健康”方法研究
Front Microbiol. 2022 Jan 26;12:797399. doi: 10.3389/fmicb.2021.797399. eCollection 2021.
10
The emerging tick-borne pathogen : first French case series and vector epidemiology.新兴蜱传病原体：法国首例病例系列及媒介流行病学。
Emerg Microbes Infect. 2021 Dec;10(1):1731-1738. doi: 10.1080/22221751.2021.1973347.
本文引用的文献
1
First case of human "Candidatus Neoehrlichia mikurensis" infection in a febrile patient with chronic lymphocytic leukemia.首例发热慢性淋巴细胞白血病患者感染“Candidatus Neoehrlichia mikurensis”。
J Clin Microbiol. 2010 May;48(5):1956-9. doi: 10.1128/JCM.02423-09. Epub 2010 Mar 10.
2
Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis.持续性感染有助于产生针对致命埃立克体病的异源保护性免疫。
Infect Immun. 2009 Dec;77(12):5682-9. doi: 10.1128/IAI.00720-09. Epub 2009 Oct 5.
3
Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis.使用基于商业通用16S rRNA基因的聚合酶链反应（PCR）和序列分析对全血样本中的菌血症进行诊断。
J Clin Microbiol. 2009 Sep;47(9):2759-65. doi: 10.1128/JCM.00567-09. Epub 2009 Jul 1.
4
Ixodes ovatus Ehrlichia exhibits unique ultrastructural characteristics in mammalian endothelial and tick-derived cells.卵形硬蜱埃立克体在哺乳动物内皮细胞和蜱源细胞中表现出独特的超微结构特征。
Ann N Y Acad Sci. 2009 May;1166:112-9. doi: 10.1111/j.1749-6632.2009.04520.x.
5
Infection by Wolbachia: from passengers to residents.沃尔巴克氏体感染：从过客到定居者。
C R Biol. 2009 Feb-Mar;332(2-3):284-97. doi: 10.1016/j.crvi.2008.09.010. Epub 2008 Dec 2.
6
Characterization of 'Candidatus Neoehrlichia lotoris' (family Anaplasmataceae) from raccoons (Procyon lotor).浣熊（北美浣熊）中“罗氏新埃立克体（暂定种）”（无形体科）的特征描述
Int J Syst Evol Microbiol. 2008 Dec;58(Pt 12):2794-8. doi: 10.1099/ijs.0.65836-0.
7
The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.嗜吞噬细胞无形体的清除需要CD4 + T细胞，但独立于Th1细胞因子和广泛的效应机制。
Eur J Immunol. 2008 Dec;38(12):3395-410. doi: 10.1002/eji.200838615.
8
T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection.非T细胞依赖的体液免疫足以抵御致死性细胞内埃立克体感染。
Infect Immun. 2007 Oct;75(10):4933-41. doi: 10.1128/IAI.00705-07. Epub 2007 Jul 30.
9
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.MEGA4：分子进化遗传学分析（MEGA）软件版本4.0。
Mol Biol Evol. 2007 Aug;24(8):1596-9. doi: 10.1093/molbev/msm092. Epub 2007 May 7.
10
Molecular survey of Babesia microti, Ehrlichia species and Candidatus neoehrlichia mikurensis in wild rodents from Shimane Prefecture, Japan.日本岛根县野生啮齿动物中微小巴贝斯虫、埃立克体属及新埃立克体（暂定名）的分子调查
Microbiol Immunol. 2007;51(4):359-67. doi: 10.1111/j.1348-0421.2007.tb03923.x.
Zotero 插件