Zier Judith L, Doescher Jason S
Department of Pediatric Critical Care, Children's Hospitals and Clinics of Minnesota, St Paul, Minnesota, USA.
J Child Neurol. 2010 Dec;25(12):1517-20. doi: 10.1177/0883073810370896. Epub 2010 Jun 2.
Nitrous oxide is an inhaled agent commonly used by dental staff to provide anxiolysis and analgesia for dental procedures and by anesthesia personnel as an adjunct to more potent general anesthetic gases. More recently, nitrous oxide has been used to provide sedation/analgesia for a variety of medical procedures in children outside of the operating room, including lumbar puncture, laceration repair, fracture reduction, and urologic imaging. We report 3 cases of clinical seizure activity associated with nitrous oxide administration for pediatric procedural sedation. Although temporally related, no causality is established. Review of the medical and dental literature confirm the rarity of these events.
一氧化二氮是一种吸入性药物，牙科工作人员常用其为牙科手术提供抗焦虑和镇痛作用，麻醉人员则将其作为更有效的全身麻醉气体的辅助药物。最近，一氧化二氮已被用于为手术室以外的各种儿科医疗程序提供镇静/镇痛，包括腰椎穿刺、伤口缝合、骨折复位和泌尿外科成像。我们报告了3例与一氧化二氮用于儿科程序镇静相关的临床癫痫发作活动病例。虽然在时间上有关联，但未确定因果关系。对医学和牙科文献的回顾证实了这些事件的罕见性。
