Unraveling the roles of WRN and DNA-PKcs at telomeres.
作者信息
Beattie Tara L, Lees-Miller Susan P
机构信息
Department of Biochemistry, The Southern Alberta Cancer Research Institute, University of Calgary, AB, Canada.
出版信息
Aging (Albany NY). 2010 May;2(5):257-8. doi: 10.18632/aging.100150.
Abstract
摘要
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Unraveling the roles of WRN and DNA-PKcs at telomeres.解析WRN和DNA-PKcs在端粒中的作用。
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Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops.DNA依赖蛋白激酶催化亚基（DNA-PKcs）与沃纳综合征解旋酶（WRN）在端粒D环维持中的协同作用。
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Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.端粒蛋白 TRF2 保护带有端粒臂的 Holliday 连接点不被 Werner 综合征解旋酶移位。
Nucleic Acids Res. 2010 Jul;38(12):3984-98. doi: 10.1093/nar/gkq144. Epub 2010 Mar 9.
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Telomeres: protecting chromosomes against genome instability.端粒：保护染色体免受基因组不稳定的影响。
Nat Rev Mol Cell Biol. 2010 Mar;11(3):171-81. doi: 10.1038/nrm2848. Epub 2010 Feb 3.
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Roles of Werner syndrome protein in protection of genome integrity. Werner 综合征蛋白在保护基因组完整性中的作用。
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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.通过非同源末端连接修复电离辐射诱导的DNA双链断裂。
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