Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik; Bad Nauheim, Germany.
Cell Cycle. 2010 Jun 15;9(12):2286-91. doi: 10.4161/cc.9.12.11907.
Cell migration is a central part of physiological and pathophysiological processes including wound healing, immune defense, matrix remodeling and organ homeostasis. Different cell types have migratory potential including cells of the immune system and cells required in wound healing and tissue repair. These cells migrate locally through the tissue to the site of damage. The fibroblast is a central cell type of wound healing. In rheumatoid arthritis (RA), activated synovial fibroblasts (SFs) have the ability to invade joint cartilage, actively contributing to joint destruction in RA. Recently, RASFs have been shown to be able to migrate to non-affected areas and joints through the blood stream and to invade distant cartilage. RASFs most likely use similar mechanisms comparable to lymphocytes and tumor cells for long-distance and vascular trans-migration. Future experiments will address the goal to keep the transformed-appearing fibroblasts in the affected joints using therapeutical strategies that inhibit the pathophysiological changes of transformed-appearing RASFs but do not interfere with the physiological processes of 'normal' fibroblasts.
细胞迁移是生理和病理生理过程的核心部分，包括伤口愈合、免疫防御、基质重塑和器官稳态。不同的细胞类型具有迁移潜力，包括免疫系统细胞和伤口愈合和组织修复所需的细胞。这些细胞通过组织局部迁移到损伤部位。成纤维细胞是伤口愈合的核心细胞类型。在类风湿关节炎 (RA) 中，活化的滑膜成纤维细胞 (SF) 具有侵袭关节软骨的能力，积极促成 RA 中的关节破坏。最近，已经表明 RASF 能够通过血液迁移到非受累区域和关节，并侵袭远处的软骨。RASF 很可能使用类似于淋巴细胞和肿瘤细胞的类似机制进行远距离和血管迁移。未来的实验将致力于使用抑制出现病理变化的 RASF 的治疗策略来阻止看起来已经转化的成纤维细胞迁移到受累关节，而不干扰“正常”成纤维细胞的生理过程。
