气味受体的新功能：MOR23 是骨骼肌正常组织修复所必需的。
A new function for odorant receptors: MOR23 is necessary for normal tissue repair in skeletal muscle.
机构信息
Department of Pharmacology, Emory University, Atlanta, GA, USA.
出版信息
Cell Adh Migr. 2010 Oct-Dec;4(4):502-6. doi: 10.4161/cam.4.4.12291.
Abstract
Myofibers with an abnormal branching cytoarchitecture are commonly found in various neuromuscular diseases as well as after severe muscle injury. These aberrant myofibers are fragile and muscles containing a high percentage of these myofibers are weaker and more prone to injury. To date the mechanisms and molecules regulating myofiber branching have been obscure. Recent work analyzing the role of mouse odorant receptor 23 (MOR23) in muscle regeneration revealed that MOR23 is necessary for proper skeletal muscle regeneration in mice as loss of MOR23 leads to increased myofiber branching. Further studies demonstrated that MOR23 expression is induced when muscle cells were extensively fusing and plays an important role in controlling cell migration and adhesion. These data demonstrate a novel role for an odorant receptor in tissue repair and identify the first molecule with a functional role in myofiber branching.
摘要
具有异常分支细胞结构的肌纤维在各种神经肌肉疾病以及严重肌肉损伤后很常见。这些异常的肌纤维很脆弱，含有高比例异常肌纤维的肌肉较弱，更容易受伤。迄今为止，调节肌纤维分支的机制和分子还不清楚。最近分析小鼠气味受体 23（MOR23）在肌肉再生中的作用的工作表明，MOR23 是小鼠正常骨骼肌再生所必需的，因为 MOR23 的缺失会导致肌纤维分支增加。进一步的研究表明，当肌肉细胞广泛融合时，MOR23 表达被诱导，并且在控制细胞迁移和黏附中发挥重要作用。这些数据表明，一种气味受体在组织修复中具有新的作用，并确定了第一个具有肌纤维分支功能作用的分子。
相似文献
1
A new function for odorant receptors: MOR23 is necessary for normal tissue repair in skeletal muscle.气味受体的新功能：MOR23 是骨骼肌正常组织修复所必需的。
Cell Adh Migr. 2010 Oct-Dec;4(4):502-6. doi: 10.4161/cam.4.4.12291.
2
Decrease of myofiber branching via muscle-specific expression of the olfactory receptor mOR23 in dystrophic muscle leads to protection against mechanical stress.通过在营养不良性肌肉中肌肉特异性表达嗅觉受体mOR23来减少肌纤维分支，可对机械应力起到保护作用。
Skelet Muscle. 2016 Jan 21;6:2. doi: 10.1186/s13395-016-0077-7. eCollection 2016.
3
MOR23 promotes muscle regeneration and regulates cell adhesion and migration.MOR23促进肌肉再生，并调节细胞黏附和迁移。
Dev Cell. 2009 Nov;17(5):649-61. doi: 10.1016/j.devcel.2009.09.004.
4
Reciprocal interaction between TRAF6 and notch signaling regulates adult myofiber regeneration upon injury.TRAF6 和 Notch 信号之间的相互作用调节损伤后成肌纤维的再生。
Mol Cell Biol. 2012 Dec;32(23):4833-45. doi: 10.1128/MCB.00717-12. Epub 2012 Oct 1.
5
Neuromuscular electrical stimulation improves skeletal muscle regeneration through satellite cell fusion with myofibers in healthy elderly subjects.神经肌肉电刺激通过与健康老年受试者的肌纤维融合来改善骨骼肌再生。
J Appl Physiol (1985). 2017 Sep 1;123(3):501-512. doi: 10.1152/japplphysiol.00855.2016. Epub 2017 Jun 1.
6
Deletion of in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in and in .小鼠骨骼肌纤维中 的缺失在 和 中诱导出与肌肉衰老相关的表型。
Mol Cell Biol. 2017 May 2;37(10). doi: 10.1128/MCB.00426-16. Print 2017 May 15.
7
Single EDL Myofiber Isolation for Analyses of Quiescent and Activated Muscle Stem Cells.用于分析静止和激活的肌肉干细胞的单根趾长伸肌肌纤维分离
Methods Mol Biol. 2018;1686:149-159. doi: 10.1007/978-1-4939-7371-2_11.
8
Incidence and severity of myofiber branching with regeneration and aging.再生和衰老过程中肌纤维分支的发生率和严重程度。
Skelet Muscle. 2014 May 15;4:9. doi: 10.1186/2044-5040-4-9. eCollection 2014.
9
Intercellular Adhesion Molecule-1 Enhances Myonuclear Transcription during Injury-Induced Muscle Regeneration.细胞间黏附分子-1 在损伤诱导的肌肉再生过程中增强肌核转录。
Int J Mol Sci. 2022 Jun 24;23(13):7028. doi: 10.3390/ijms23137028.
10
Co-delivery of Wnt7a and muscle stem cells using synthetic bioadhesive hydrogel enhances murine muscle regeneration and cell migration during engraftment.利用合成生物黏附水凝胶共递送 Wnt7a 和肌肉干细胞可增强移植过程中鼠类肌肉再生和细胞迁移。
Acta Biomater. 2019 Aug;94:243-252. doi: 10.1016/j.actbio.2019.06.025. Epub 2019 Jun 19.
引用本文的文献
1
Lifespan Analysis of Dystrophic Fast-Twitch Muscle Morphology and Its Impact on Contractile Function.营养不良性快肌形态的寿命分析及其对收缩功能的影响。
Front Physiol. 2021 Dec 7;12:771499. doi: 10.3389/fphys.2021.771499. eCollection 2021.
2
Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Expression.核孔蛋白 TPR 通过调控 表达影响 C2C12 成肌分化。
Cells. 2021 May 21;10(6):1271. doi: 10.3390/cells10061271.
3
Olfaction: Smell of Change in the Air.嗅觉：空气中变化的气味。
Cerebrum. 2017 Jul 1;2017. eCollection 2017 Jul-Aug.
4
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells an Ectopic Olfactory Receptor.一种睾酮代谢物19-羟基雄烯二酮诱导前列腺癌细胞发生神经内分泌转分化——一种异位嗅觉受体。
Front Oncol. 2018 May 28;8:162. doi: 10.3389/fonc.2018.00162. eCollection 2018.
5
The essence of appetite: does olfactory receptor variation play a role?食欲的本质：嗅觉受体的变异是否起作用？
J Anim Sci. 2018 Apr 14;96(4):1551-1558. doi: 10.1093/jas/sky068.
6
The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way.从多能性到骨骼肌的路径：发育性肌生成引领方向。
Cell Stem Cell. 2015 Sep 3;17(3):255-7. doi: 10.1016/j.stem.2015.08.017.
7
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.将多能干细胞分化为肌纤维，以模拟杜氏肌营养不良症。
Nat Biotechnol. 2015 Sep;33(9):962-9. doi: 10.1038/nbt.3297. Epub 2015 Aug 3.
8
Incidence and severity of myofiber branching with regeneration and aging.再生和衰老过程中肌纤维分支的发生率和严重程度。
Skelet Muscle. 2014 May 15;4:9. doi: 10.1186/2044-5040-4-9. eCollection 2014.
9
Profiling of olfactory receptor gene expression in whole human olfactory mucosa.人嗅黏膜嗅受体基因表达谱分析。
PLoS One. 2014 May 6;9(5):e96333. doi: 10.1371/journal.pone.0096333. eCollection 2014.
10
The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis.N-BAR 域蛋白 Bin3 调节成肌细胞中 Rac1 和 Cdc42 依赖的过程。
Dev Biol. 2013 Oct 1;382(1):160-71. doi: 10.1016/j.ydbio.2013.07.004. Epub 2013 Jul 16.
本文引用的文献
1
Olfactory signalling in vertebrates and insects: differences and commonalities.脊椎动物和昆虫的嗅觉信号：差异与共性。
Nat Rev Neurosci. 2010 Mar;11(3):188-200. doi: 10.1038/nrn2789. Epub 2010 Feb 10.
2
MOR23 promotes muscle regeneration and regulates cell adhesion and migration.MOR23促进肌肉再生，并调节细胞黏附和迁移。
Dev Cell. 2009 Nov;17(5):649-61. doi: 10.1016/j.devcel.2009.09.004.
3
Nap1-mediated actin remodeling is essential for mammalian myoblast fusion.Nap1介导的肌动蛋白重塑对于哺乳动物成肌细胞融合至关重要。
J Cell Sci. 2009 Sep 15;122(Pt 18):3282-93. doi: 10.1242/jcs.047597. Epub 2009 Aug 25.
4
Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling.畸形的mdx肌纤维具有正常的细胞骨架结构，但兴奋-收缩偶联和应激诱导的Ca2+信号传导发生了改变。
Am J Physiol Cell Physiol. 2009 Sep;297(3):C571-80. doi: 10.1152/ajpcell.00087.2009. Epub 2009 Jul 15.
5
Activation of an olfactory receptor inhibits proliferation of prostate cancer cells.嗅觉受体的激活会抑制前列腺癌细胞的增殖。
J Biol Chem. 2009 Jun 12;284(24):16218-16225. doi: 10.1074/jbc.M109.012096. Epub 2009 Apr 23.
6
Update on the olfactory receptor (OR) gene superfamily.嗅觉受体（OR）基因超家族的最新进展。
Hum Genomics. 2008 Sep;3(1):87-97. doi: 10.1186/1479-7364-3-1-87.
7
Branched fibers in dystrophic mdx muscle are associated with a loss of force following lengthening contractions.营养不良性肌萎缩（mdx）肌肉中的分支纤维与拉长收缩后力量丧失有关。
Am J Physiol Cell Physiol. 2007 Sep;293(3):C985-92. doi: 10.1152/ajpcell.00128.2007. Epub 2007 Jun 13.
8
A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting.一种用于嗅觉受体特异性和活性依赖性轴突分选的神经元身份编码。
Cell. 2006 Dec 1;127(5):1057-69. doi: 10.1016/j.cell.2006.10.031.
9
Odorant receptor-derived cAMP signals direct axonal targeting.嗅觉受体衍生的环磷酸腺苷信号引导轴突靶向。
Science. 2006 Oct 27;314(5799):657-61. doi: 10.1126/science.1131794. Epub 2006 Sep 21.
10
Widespread ectopic expression of olfactory receptor genes.嗅觉受体基因的广泛异位表达。
BMC Genomics. 2006 May 22;7:121. doi: 10.1186/1471-2164-7-121.
Zotero 插件