Melwani Priti M, Parsons Amy C, Sangueza Omar P
Department of Dermatology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Am J Dermatopathol. 2010 Aug;32(6):565-7. doi: 10.1097/DAD.0b013e3181cb3fbe.
Grover disease is a clinicopathologic entity characterized by acantholysis. The histologic changes typically occupy circumscribed foci, therefore early stages could go unnoticed and be misdiagnosed.
To report on early histopathologic changes in Grover disease.
We analyzed 22 cases of Grover disease histologically diagnosed at Wake Forest University School of Medicine, NC, between 2000 and 2009. Early changes were defined as elongation of rete ridges and mild focal acantholysis.
Six cases (27%) showed elongation of the rete ridges with focal acantholysis. Mild spongiosis was seen in 4 cases. Superficial perivascular inflammatory infiltrate was found in all cases, 5 of which showed eosinophils.
These findings may represent a diagnostic clue in cases of early Grover disease, if clinical correlation is made.
格罗弗病是一种以棘层松解为特征的临床病理实体。组织学改变通常局限于特定病灶，因此早期阶段可能未被注意到并被误诊。
报告格罗弗病的早期组织病理学变化。
我们分析了2000年至2009年期间在北卡罗来纳州维克森林大学医学院经组织学诊断的22例格罗弗病病例。早期变化定义为 rete 嵴延长和轻度局灶性棘层松解。
6例（27%）表现为 rete 嵴延长伴局灶性棘层松解。4例可见轻度海绵形成。所有病例均发现浅表血管周围炎性浸润，其中5例可见嗜酸性粒细胞。
如果结合临床，这些发现可能为早期格罗弗病病例提供诊断线索。
