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皮肤角:222例病例的回顾性组织病理学研究

Cutaneous horn: a retrospective histopathological study of 222 cases.

作者信息

Mantese Sônia Antunes de Oliveira, Diogo Priscila Miranda, Rocha Ademir, Berbert Alceu Luiz Camargo Villela, Ferreira Ana Karolina Mariano, Ferreira Thais Camargos

机构信息

Universidade Federal de Uberlândia, MG, Brasil.

出版信息

An Bras Dermatol. 2010 Mar-Apr;85(2):157-63. doi: 10.1590/s0365-05962010000200005.

Abstract

BACKGROUND

Cutaneous horn is a keratotic, conical and circumscribed lesion that can hide both benign or malignant lesions.

OBJECTIVE

To identify,from a histopathological point of view, the main clinical dermatoses that are presented ,from a clinical point of view, as cutaneous horn.

METHODS

RETROSPECTIVE HISTOPATHOLOGICAL STUDY OF 222 CASES OF CUTANEOUS HORNS THAT WERE CLASSIFIED AS SUCH BY ANATOMICAL-PATHOLOGICAL REPORTS OF THE UNIVERSITY HOSPITAL (HOSPITAL DE CLINICAS DE UBERLANDIA) FROM 1990 TO 2006.

RESULTS

The average age of patients was 67,42. The female sex was more affected (64,86%). The average time of clinical evolution was 16,92 months. Lesions were mostly frequent located on the head (35,14%) and upper limbs (31,08%). Histopathological analysis considered 41,44 % of the lesions as benign and 58,56% as pre-malignant or malignant among the 222 cases of cutaneous horns studied. Within the group of pre-malignant lesions, actinic keratosis was found in 83,84% of the cases; within the group of malignant lesions, squamous cell carcinoma was found in 93,75% of the cases.

CONCLUSIONS

This study showed that the majority of cutaneosus horns occured in areas of the body that are exposed to the sun, predominantly head and upper limbs. Considering the high frequency of pre-malignant lesions and also the presence of malignant lesions it is suggested surgical exeresis followed by histopathological study of the cutaneous horns for confirmation of specific diagnosis.

摘要

背景

皮肤角是一种角化性、圆锥形且边界清晰的损害,其下可能隐匿着良性或恶性病变。

目的

从组织病理学角度鉴别临床上表现为皮肤角的主要皮肤病。

方法

对222例皮肤角病例进行回顾性组织病理学研究,这些病例由乌贝兰迪亚大学医院(Hospital de Clínicas de Uberlândia)1990年至2006年的解剖病理学报告归类为此类。

结果

患者的平均年龄为67.42岁。女性受累更多(64.86%)。临床演变的平均时间为16.92个月。病变最常位于头部(35.14%)和上肢(31.08%)。在研究的222例皮肤角病例中,组织病理学分析认为41.44%的病变为良性,58.56%为癌前或恶性。在癌前病变组中,83.84%的病例发现日光性角化病;在恶性病变组中,93.75%的病例发现鳞状细胞癌。

结论

本研究表明,大多数皮肤角发生在身体暴露于阳光的部位,主要是头部和上肢。鉴于癌前病变的高发生率以及恶性病变的存在,建议对皮肤角进行手术切除,随后进行组织病理学研究以确诊。

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