Hohmann Clarissa Barlem, Köche Bruna, Bonamigo Renan Rangel, Dornelles Sérgio Torres, Cattani Cristiane Almeida Soares
Public Health Dermatology Outpatient Clinic, Porto Alegre, RS, Brazil.
An Bras Dermatol. 2010 Mar-Apr;85(2):241-3. doi: 10.1590/s0365-05962010000200020.
Dowling-Degos disease is a rare genodermatosis characterized principally by progressive reticulate hyperpigmentation of the flexures. Although the condition is benign, it may be associated with skin malignancies. Furthermore, the characteristic skin changes may be psychologically and socially detrimental to the patient as a result of the unsightliness of the condition. The present report describes a case in which this disease was associated with a keratoacanthoma, and summarizes current concepts on this skin disorder.
Dowling-Degos病是一种罕见的遗传性皮肤病，主要特征为屈侧进行性网状色素沉着。尽管该病为良性，但可能与皮肤恶性肿瘤有关。此外，由于病情外观不佳，其特征性的皮肤改变可能在心理和社交方面对患者产生不利影响。本报告描述了一例该疾病与角化棘皮瘤相关的病例，并总结了关于这种皮肤疾病的当前概念。
