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道林-迪戈斯病、化脓性汗腺炎和多发性角化棘皮瘤。一种可能由毛囊皮脂腺上皮增殖的单一潜在缺陷引起的疾病。

Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation.

作者信息

Fenske N A, Groover C E, Lober C W, Espinoza C G

机构信息

Division of Dermatology, USF College of Medicine, Tampa 33612.

出版信息

J Am Acad Dermatol. 1991 May;24(5 Pt 2):888-92.

PMID:2050858
Abstract

We report a case in which one patient had Dowling-Degos disease (reticulate pigmented anomaly of the flexures), hidradenitis suppurativa, and multiple keratoacanthomas. Abnormal epithelial proliferation involving mainly the pilosebaceous apparatus has been recognized in all three conditions. We speculate that a single underlying defect in follicular epithelial proliferation, characterized by variable expressivity, accounts for the coexistence of these clinically distinct disorders of follicular derivation.

摘要

我们报告了一例患者，其患有Dowling-Degos病（屈侧网状色素异常）、化脓性汗腺炎和多发性角化棘皮瘤。在这三种病症中均已认识到主要累及毛囊皮脂腺单位的异常上皮增殖。我们推测，以可变表达为特征的毛囊上皮增殖中的单一潜在缺陷，解释了这些临床上不同的毛囊源性疾病的共存。

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J Am Acad Dermatol. 1991 May;24(5 Pt 2):888-92.
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