从心脏门控最大后验重建 PET 图像中获取小鼠的图像衍生输入函数。
Image-derived input function from cardiac gated maximum a posteriori reconstructed PET images in mice.
机构信息
Department of Biomedical Engineering, The University of Virginia, P.O. Box 801339, 480 Ray C Hunt Drive, Snyder Building, Charlottesville, VA 22908, USA.
出版信息
Mol Imaging Biol. 2011 Apr;13(2):342-7. doi: 10.1007/s11307-010-0347-4.
PURPOSE
The purpose of this study was to determine if accurate image-derived input functions (IDIF) can be measured from cardiac gated positron emission tomography (PET) images reconstructed using ordered subset expectation maximization-maximum a posteriori (OSEM-MAP) without further correction.
PROCEDURES
IDIFs from the left ventricle were measured from cardiac gated PET images reconstructed using OSEM-MAP with computed tomography (CT)-based attenuation correction for five C57/BL6 mice. The accuracy of the IDIF was tested against blood samples using Bland-Altman analysis.
RESULTS
Image-derived blood radioactivity concentration values were not significantly different from sampled blood values at two late time points as determined by a paired t test (P = 0.97). Bland-Altman analysis revealed a mean difference of 0.06 μCi/ml (1%). Using kinetic analysis, the mean myocardial 2-deoxy-2-[(18)F]fluoro-D-glucose uptake rate constant based on the IDIF was comparable to values reported in the literature based on physical blood sampling.
CONCLUSIONS
Accurate IDIFs can be obtained non-invasively. Although reconstruction times are increased, no further spillover corrections are necessary for IDIFs derived from gated, OSEM-MAP reconstructed images with attenuation correction.
目的
本研究旨在确定是否可以从使用有序子集期望最大化-最大后验估计（OSEM-MAP）重建的门控正电子发射断层扫描（PET）图像中测量准确的基于图像的输入函数（IDIF），而无需进一步校正。
过程
从使用基于 CT 的衰减校正的 OSEM-MAP 重建的心脏门控 PET 图像中测量左心室的 IDIF，用于 5 只 C57/BL6 小鼠。使用 Bland-Altman 分析测试 IDIF 的准确性与血样对照。
结果
通过配对 t 检验（P = 0.97）确定，图像衍生的血液放射性浓度值在两个晚期时间点与采样血液值没有显着差异。Bland-Altman 分析显示平均差异为 0.06 μCi/ml（1%）。使用动力学分析，基于 IDIF 的心肌 2-脱氧-2-[[18]F]氟-D-葡萄糖摄取率常数与文献中基于物理血液采样报告的值相当。
结论
可以无创地获得准确的 IDIF。尽管重建时间增加，但对于具有衰减校正的门控、OSEM-MAP 重建图像，衍生的 IDIF 无需进行进一步的溢出校正。
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