Medicinal Plant Herbarium, Southern Cross University, 157, Lismore NSW 2480, Australia.
Biol Pharm Bull. 2010;33(6):1015-8. doi: 10.1248/bpb.33.1015.
Passionflower (Passiflora incarnata L.) is used in phytotherapy as a mild sedative and anxiolytic agent. In the literature it is clear this plant shows considerable qualitative and quantitative variability with respect to its content of C-glycosyl flavones, some of which are used as marker compounds for extracts. Analysis of plant material cultivated in Australia revealed two chemically distinct groups; hence an investigation was carried out to determine whether distinct intraspecific chemotypes exist in this species. Eleven P. incarnata samples were analysed by HPLC, LC-MS and two different TLC methods. The samples fell into two distinct groups with respect to their C-glycosyl flavone profile, with little within-group variation. One chemotype was dominated by isovitexin and schaftoside/isoschaftoside, as is most widely reported in the literature for this species. The other chemotype was characterized by a high level of swertisin, with low levels of schaftoside/isoschaftoside. The two chemotypes are readily identified by both HPLC and TLC. Although the compounds responsible for the therapeutic activity of P. incarnata are yet to be identified, phytomedicines should be made with the accepted isovitexin chemotype until the pharmacological implications of chemotypical differences are understood.
西番莲（Passiflora incarnata L.）在植物疗法中被用作温和的镇静剂和抗焦虑剂。文献清楚地表明，这种植物在其 C-糖苷类黄酮的含量方面表现出相当大的定性和定量变异性，其中一些被用作提取物的标记化合物。对在澳大利亚种植的植物材料进行分析后发现有两个化学上明显不同的群体；因此，进行了一项研究，以确定在该物种中是否存在不同的种内化学型。通过 HPLC、LC-MS 和两种不同的 TLC 方法对 11 个西番莲样本进行了分析。这些样品在其 C-糖苷类黄酮图谱方面分为两个不同的组，组内变化很小。一种化学型以异荭草苷和荭草苷/异荭草苷为主，这是该物种在文献中最广泛报道的。另一种化学型以高水平的獐牙菜苦苷为特征，荭草苷/异荭草苷水平较低。两种化学型都可以通过 HPLC 和 TLC 轻松识别。尽管西番莲具有治疗作用的化合物尚未确定，但在理解化学型差异的药理学意义之前，应使用公认的异荭草苷化学型制造植物药。
