原口动物门糖鞘脂的合成研究：曼氏血吸虫糖鞘脂的合成

Synthetic studies on glycosphingolipids from protostomia phyla: synthesis of glycosphingolipids from the parasite Schistosoma mansoni.

作者信息

Kanaya Takayuki, Yagi Satomi, Schweizer Frank, Takeda Tadahiro, Kiuchi Fumiyuki, Hada Noriyasu

机构信息

Faculty of Pharmacy, Keio University.

出版信息

Chem Pharm Bull (Tokyo). 2010 Jun;58(6):811-7. doi: 10.1248/cpb.58.811.

DOI:10.1248/cpb.58.811

PMID:20522991

Abstract

Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. These structures differ significantly from those of other parasites and exhibit a unique structural motif termed "schisto-core" consisting of GalNAcbeta1-->4Glcbeta1-->sequence. We have synthesized glycosphingolipids, beta-D-GalNAcp-(1-->4)-beta-D-Glcp-(1-->1)Cer (1), beta-D-GlcNAcp-(1-->3)-beta-D-GalNAcp-(1-->4)-beta-D-Glcp-(1-->1)Cer (2) and beta-D-Galp-(1-->4)-beta-D-GlcNAcp-(1-->3)-beta-D-GalNAcp-(1-->4)-beta-D-Glcp-(1-->1)Cer (3).

摘要

已成功实现从曼氏血吸虫成虫中合成三种中性糖鞘脂。这些结构与其他寄生虫的结构有显著差异，并呈现出一种独特的结构基序，称为“血吸虫核心”，由GalNAcbeta1-->4Glcbeta1-->序列组成。我们已经合成了糖鞘脂，β-D-GalNAcp-(1-->4)-β-D-Glcp-(1-->1)Cer (1)、β-D-GlcNAcp-(1-->3)-β-D-GalNAcp-(1-->4)-β-D-Glcp-(1-->1)Cer (2) 和 β-D-Galp-(1-->4)-β-D-GlcNAcp-(1-->3)-β-D-GalNAcp-(1-->4)-β-D-Glcp-(1-->1)Cer (3)。