Kellerman T S, Erasmus G L, Coetzer J A, Brown J M, Maartens B P
Veterinary Research Institute, Onderstepoort, Republic of South Africa.
Onderstepoort J Vet Res. 1991 Mar;58(1):47-53.
Geeldikkop was induced in sheep by the oral administration of crude steroidal saponins from Tribulus terrestris. Two of the sheep developed typical lesions of geeldikkop, including birefringent crystalloid material in bile ducts and concentric periductal lamellar fibrosis. The clinical pathological changes in these sheep were also consistent with those of geeldikkop: aspartate transaminase and gamma-glutamyl transferase activities in the sera of both were elevated, and one had bilirubinaemia. A third sheep became photosensitive without typical lesions of geeldikkop in the liver or changes in the activities of liver enzymes before euthanasia. The findings of these trials are consistent with reports from abroad that ovine hepatogenous photosensitization, caused by Agave lechuguilla and Narthecium ossifragum, can be induced with crude saponins from the respective plants.
通过给绵羊口服刺蒺藜中的粗甾体皂苷来诱发黄胆病。其中两只绵羊出现了典型的黄胆病病变，包括胆管中的双折射晶体物质和同心性胆管周围层状纤维化。这些绵羊的临床病理变化也与黄胆病相符：两只绵羊血清中的天冬氨酸转氨酶和γ-谷氨酰转移酶活性均升高，其中一只出现胆红素血症。第三只绵羊在安乐死之前变得光敏，但肝脏中没有典型的黄胆病病变，肝酶活性也没有变化。这些试验结果与国外的报道一致，即龙舌兰和碎米荠引起的绵羊肝源性光敏反应可以用各自植物中的粗皂苷诱发。
