Cheong Seung Hyun, Lim Ji Yeon, Kim So Young, Choi You Won, Choi Hae Young, Myung Ki Bum
Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
Ann Dermatol. 2009 Aug;21(3):304-7. doi: 10.5021/ad.2009.21.3.304. Epub 2009 Aug 31.
Eccrine angiomatous hamartomas are benign vascular and eccrine malformations often accompanied by hyperhidrosis or pain, increased eccrine glands, and aggregates of vessels. Verrucous hemangiomas are congenital vascular malformations presenting as unilateral grouped papules. Histologically, they show verrucous epidermal change and proliferation of capillaries in the dermis. We report a case of a 47-year-old woman with a red keratotic patch overlying a bluish plaque on the right sole, which had been present since birth. It was accompanied by pain and hyperhidrosis. Histologically, there were verrucous changes in the epidermis, numerous dilated capillaries in the papillary dermis, and increased eccrine glands with angiomatous foci in the deep dermis. The epithelial cells of the eccrine glands were positive for CEA, and the endothelial cells were positive for CD31 and GLUT-1. Eccrine angiomatous hamartomas have been reported in conjunction with other vascular tumors in only a few instances. We report an interesting case of an eccrine angiomatous hamartoma associated with a verrucous hemangioma.
小汗腺血管瘤性错构瘤是良性血管和小汗腺畸形,常伴有多汗症或疼痛、小汗腺增多以及血管聚集。疣状血管瘤是先天性血管畸形,表现为单侧群集性丘疹。组织学上,它们显示疣状表皮改变和真皮内毛细血管增生。我们报告一例47岁女性病例,其右足底有一个红色角化斑块覆盖在蓝色斑块上,自出生以来就存在。伴有疼痛和多汗症。组织学上,表皮有疣状改变,乳头真皮内有大量扩张的毛细血管,深部真皮内小汗腺增多并伴有血管瘤病灶。小汗腺上皮细胞CEA阳性,内皮细胞CD31和GLUT - 1阳性。小汗腺血管瘤性错构瘤仅在少数情况下与其他血管肿瘤同时报道。我们报告一例有趣的小汗腺血管瘤性错构瘤合并疣状血管瘤的病例。