Lee Eun, Cho Sang Hyun, Park Chul Jong
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Dermatol. 2009 Nov;21(4):345-51. doi: 10.5021/ad.2009.21.4.345. Epub 2009 Nov 30.
Mucoceles have diverse clinical and histological features. Their pathogenesis remains to be elucidated.
To determine the structural and/or pathogenic differences between two clinically different types of mucoceles.
Seventeen oral mucoceles were examined clinically and immunohistologically. The mucoceles were divided into two groups by their clinical manifestations: papular group (PG) and nodular group (NG).
Histologically, granulation tissue formed more frequently in the NG group, while CD4 and CD8 positive cells were more abundant in the PG group. There were no significant differences in the tumor necrosis factor-alpha or the matrix metalloproteinases (MMP)-2 and 9, between the two groups.
There were significant differences in the depth of the lesions, granulation tissue formation and infiltrating T lymphocytes between the PG and NP type of mucoceles. These findings suggest that the clinical manifestations may be influenced by the type of inflammatory response and extracellular matrix remodeling.
黏液囊肿具有多样的临床和组织学特征。其发病机制仍有待阐明。
确定两种临床不同类型黏液囊肿之间的结构和/或致病差异。
对17例口腔黏液囊肿进行临床和免疫组织学检查。根据临床表现将黏液囊肿分为两组：丘疹组（PG）和结节组（NG）。
组织学上，NG组更常形成肉芽组织，而PG组中CD4和CD8阳性细胞更为丰富。两组之间肿瘤坏死因子-α或基质金属蛋白酶（MMP）-2和9无显著差异。
PG型和NP型黏液囊肿在病变深度、肉芽组织形成和浸润性T淋巴细胞方面存在显著差异。这些发现表明，临床表现可能受炎症反应类型和细胞外基质重塑的影响。
