Musunuru Kiran
Cardiology Division, Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, CPZN 5th floor, Boston, MA 02114, USA.
Lipids. 2010 Oct;45(10):907-14. doi: 10.1007/s11745-010-3408-1. Epub 2010 Jun 4.
Atherogenic dyslipidemia comprises a triad of increased blood concentrations of small, dense low-density lipoprotein (LDL) particles, decreased high-density lipoprotein (HDL) particles, and increased triglycerides. A typical feature of obesity, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus, atherogenic dyslipidemia has emerged as an important risk factor for myocardial infarction and cardiovascular disease. A number of genes have now been linked to this pattern of lipoprotein changes. Low-carbohydrate diets appear to have beneficial lipoprotein effects in individuals with atherogenic dyslipidemia, compared to high-carbohydrate diets, whereas the content of total fat or saturated fat in the diet appears to have little effect. Achieving a better understanding of the genetic and dietary influences underlying atherogenic dyslipidemia may provide clues to improved interventions to reduce the risk of cardiovascular disease in high-risk individuals.
致动脉粥样硬化性血脂异常包括血液中浓度升高的小而密低密度脂蛋白（LDL）颗粒、高密度脂蛋白（HDL）颗粒减少以及甘油三酯升高这三个特征。作为肥胖、代谢综合征、胰岛素抵抗和2型糖尿病的典型特征，致动脉粥样硬化性血脂异常已成为心肌梗死和心血管疾病的重要危险因素。现在已经有许多基因与这种脂蛋白变化模式相关联。与高碳水化合物饮食相比，低碳水化合物饮食似乎对致动脉粥样硬化性血脂异常患者的脂蛋白有有益影响，而饮食中总脂肪或饱和脂肪的含量似乎影响不大。更好地了解致动脉粥样硬化性血脂异常背后的遗传和饮食影响，可能为改善干预措施提供线索，以降低高危个体患心血管疾病的风险。
