Siddiqui Nadeem, ur Rahman Mujeeb, Arshad M Faiz, Ahsan Waquar, Alam M Shamsher, Ahmed Sharique
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
Acta Pol Pharm. 2010 May-Jun;67(3):239-46.
Various N,N'-diaryl-1,3-thiazole-2,4-diamines (3a-w) were synthesized by a three steps process. The structures of the synthesized compounds were confirmed by spectral data and elemental analyses. All the synthesized compounds were tested against two bacterial strains and two fungal strains. Bacterial strains included Gram positive Staphylococcus aureus and Gram negativeve Escherichia coli and fungal strains included Monascus purpurea and Penicillium citrinum. Most of the compounds showed moderate to good antibacterial as well as antifungal activity.
通过三步法合成了各种N,N'-二芳基-1,3-噻唑-2,4-二胺（3a-w）。通过光谱数据和元素分析确定了合成化合物的结构。对所有合成化合物针对两种细菌菌株和两种真菌菌株进行了测试。细菌菌株包括革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌，真菌菌株包括红曲霉和桔青霉。大多数化合物表现出中度至良好的抗菌和抗真菌活性。
