Bamrungsong Tachchai, Pongchaiyakul Chatlert
Department of Orthopedics, Phranakhon Si Ayutthaya Hospital, Phranakhon Si Ayutthaya, Thailand.
J Med Assoc Thai. 2010 May;93(5):620-4.
Bisphosphonates therapy has been shown to decrease the risk of vertebral, non-vertebral, and hip fractures in postmenopausal women. However the long-term safety of bisphosphonates use has been questioned. Recent reports have demonstrated the association between long-term alendronate therapy with low-energy subtrochanteric fracture or diaphyseal femoral fractures in a small number of patients. The author reported the first case of bilateral atypical femoral fractures in postmenopausal women with osteoporosis receiving long-term alendronate therapy.
双膦酸盐疗法已被证明可降低绝经后女性发生椎体、非椎体和髋部骨折的风险。然而，双膦酸盐使用的长期安全性受到了质疑。最近的报告显示，少数患者长期使用阿仑膦酸盐治疗与低能量股骨转子下骨折或股骨干骨折之间存在关联。作者报告了首例接受长期阿仑膦酸盐治疗的绝经后骨质疏松女性双侧非典型股骨骨折病例。
