Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
J Am Chem Soc. 2010 Jun 30;132(25):8569-71. doi: 10.1021/ja1026248.
A palladium-catalyzed chelation-assisted C-H activation of alkyl aryl ketones and their reaction with aryl iodides to afford ortho-arylated products is described. For sec-alkyl aryl ketones, the catalytic reaction proceeds further to give 10,10-dialkylphenanthrone derivatives. A possible reaction mechanism involving directed dual C-H bond activation and enolate cyclization for the formation of 10,10-dialkylphenanthrone derivatives is proposed.
钯催化的烷基芳基酮的螯合辅助 C-H 活化及其与芳基碘化物的反应，以提供邻芳基化产物被描述。对于 sec-烷基芳基酮，催化反应进一步进行，得到 10,10-二烷基菲啶酮衍生物。提出了一种可能的反应机制，涉及定向双 C-H 键活化和烯醇环化，用于形成 10,10-二烷基菲啶酮衍生物。
