Academy for Advanced Interdisciplinary Studies and Institute of Vascular Medicine of Third Hospital, Ministry of Education Key Lab of Molecular Cardiovascular Sciences, Peking University, Beijing, 100191, China.
ACS Nano. 2010 Jun 22;4(6):3015-22. doi: 10.1021/nn1002198.
In this work, we reported that the quantum dot (QD) nanoparticles could be actively transported in the membrane nanotubes between cardiac myocytes. Single particle imaging and tracking of QDs revealed that most QDs moved in a bidirectional mode along the membrane nanotubes with a mean velocity of 1.23 mum/s. The results suggested that QDs moving in the nanotubes were coordinately motivated by molecular motors. It provides new information for the study of intercellular transportation of nanoparticles.
在这项工作中，我们报告说量子点（QD）纳米粒子可以在心肌细胞之间的膜纳米管中被主动运输。QD 的单粒子成像和跟踪显示，大多数 QD 以双向模式沿着膜纳米管以 1.23 µm/s 的平均速度移动。结果表明，在纳米管中移动的 QD 是由分子马达协调驱动的。这为研究纳米粒子的细胞间运输提供了新的信息。
