To Kelvin K W, Wong Samson S Y, Cheng Vincent C C, Tang Bone S F, Li Iris W S, Chan Jasper F W, Seto Wai-Kay, Tse Herman, Yuen Kwok-Yung
Infectious Disease Division, Queen Mary Hospital, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
Scand J Infect Dis. 2010 Oct;42(10):757-62. doi: 10.3109/00365548.2010.490562.
Shewanella is a rare human pathogen that can lead to fatal infections. However, clinical information about this bacterium remains scarce. In this study, we retrospectively reviewed all patients with laboratory isolates of Shewanella over an 8-y period to assess risk factors, clinical manifestations and outcome. Twenty-nine patients were identified. Shewanella was most commonly isolated from intra-abdominal specimens (48.2%), followed by skin and soft tissue specimens (27.6%), blood (13.8%) and sputum (10.3%). Malignancy, hepatobiliary disease and diabetes mellitus were common underlying diseases. The overall 30-day mortality rate was 20.6%. Shewanella was considered a definite causative pathogen in 7 patients, and a recurrent infection occurred in 2 patients. Colonization of the biliary tract was common. Among co-isolated pathogens, the enteric flora was most represented. All isolates were susceptible to ceftazidime and aminoglycosides, but 1 isolate was resistant to imipenem. In conclusion, Shewanella may become a colonizing bacterium, subsequently causing invasive diseases in patients with an underlying disease.
希瓦氏菌是一种罕见的人类病原体，可导致致命感染。然而，关于这种细菌的临床信息仍然很少。在本研究中，我们回顾性分析了8年间所有实验室分离出希瓦氏菌的患者，以评估危险因素、临床表现和预后。共确定了29例患者。希瓦氏菌最常从腹腔内标本中分离出来（48.2%），其次是皮肤和软组织标本（27.6%）、血液（13.8%）和痰液（10.3%）。恶性肿瘤、肝胆疾病和糖尿病是常见的基础疾病。总体30天死亡率为20.6%。7例患者中希瓦氏菌被认为是明确的致病病原体，2例患者发生了复发性感染。胆道定植很常见。在共同分离出的病原体中，肠道菌群最为常见。所有分离株对头孢他啶和氨基糖苷类药物敏感，但1株对亚胺培南耐药。总之，希瓦氏菌可能成为一种定植菌，随后在有基础疾病的患者中引起侵袭性疾病。
